Home > Publications Database > Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults. > print

001     281854
005     20251117104419.0
024 7 _ |a 10.1038/s41598-025-21596-0
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024 7 _ |a pmid:41188354
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037 _ _ |a DZNE-2025-01227
041 _ _ |a English
082 _ _ |a 600
100 1 _ |a Fischer, Larissa
|0 P:(DE-2719)9002356
|b 0
|e First author
245 _ _ |a Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults.
260 _ _ |a [London]
|c 2025
|b Springer Nature
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Changes in functional connectivity (FC) strength involving the medial temporal lobe (MTL) and posteromedial cortex (PMC) are related to early Alzheimer's pathology and alterations in episodic memory performance in cognitively unimpaired older adults, but their dynamics remain unclear. We examined how longitudinal changes in FC involving MTL and PMC during resting-state, episodic memory encoding, and retrieval relate to subsequent amyloid- and tau-PET burden, longitudinal episodic memory performance, and the APOE4 genotype in 152 cognitively unimpaired older adults from the PREVENT-AD cohort. We found APOE4- and fMRI paradigm-dependent associations of change in FC strength with pathology burden and change in episodic memory performance. Decreasing FC over time, or 'hypoconnectivity', within PMC during rest in APOE4 carriers and during retrieval in APOE4 non-carriers was related to more amyloid and tau, respectively. Conversely, increasing FC over time, or 'hyperconnectivity', within MTL during encoding in APOE4 carriers and between MTL and PMC during retrieval independent of APOE4 status was related to more tau. Further, increasing FC between MTL and PMC during rest, unlike during encoding, was beneficial for episodic memory. Our study highlights that pathology-related episodic memory network changes manifest differently during rest and task and have differential implications for episodic memory trajectories.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a APOE4
|2 Other
650 _ 7 |a Aging
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Episodic memory
|2 Other
650 _ 7 |a Functional connectivity
|2 Other
650 _ 7 |a fMRI
|2 Other
650 _ 7 |a Apolipoprotein E4
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Memory, Episodic
|2 MeSH
650 _ 2 |a Alzheimer Disease: physiopathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnostic imaging
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Apolipoprotein E4: genetics
|2 MeSH
650 _ 2 |a Rest: physiology
|2 MeSH
650 _ 2 |a Temporal Lobe: physiopathology
|2 MeSH
650 _ 2 |a Temporal Lobe: diagnostic imaging
|2 MeSH
650 _ 2 |a Temporal Lobe: pathology
|2 MeSH
650 _ 2 |a tau Proteins: metabolism
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Positron-Emission Tomography
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
700 1 _ |a Adams, Jenna N
|0 0000-0002-6702-3851
|b 1
700 1 _ |a Molloy, Eóin N.
|0 P:(DE-2719)9002180
|b 2
700 1 _ |a Tremblay-Mercier, Jennifer
|b 3
700 1 _ |a Remz, Jordana
|b 4
700 1 _ |a Binette, Alexa Pichet
|0 0000-0001-5218-3337
|b 5
700 1 _ |a Rajah, M Natasha
|b 6
700 1 _ |a Villeneuve, Sylvia
|0 0000-0003-2338-0467
|b 7
700 1 _ |a Maass, Anne
|0 P:(DE-2719)2811815
|b 8
|e Last author
700 1 _ |a Group, PREVENT-AD Research
|b 9
|e Collaboration Author
700 1 _ |a Poirier, Judes
|b 10
|e Contributor
700 1 _ |a Breitner, John C S
|b 11
|e Contributor
700 1 _ |a Badawy, Mohamed
|b 12
|e Contributor
700 1 _ |a Baillet, Sylvain
|b 13
|e Contributor
700 1 _ |a Baril, Andrée-Ann
|b 14
|e Contributor
700 1 _ |a Bellec, Pierre
|b 15
|e Contributor
700 1 _ |a Bohbot, Véronique
|b 16
|e Contributor
700 1 _ |a Bzdok, Danilo
|b 17
|e Contributor
700 1 _ |a Chakravarty, Mallar
|b 18
|e Contributor
700 1 _ |a Collins, D Louis
|b 19
|e Contributor
700 1 _ |a Dadar, Mahsa
|b 20
|e Contributor
700 1 _ |a Ducharme, Simon
|b 21
|e Contributor
700 1 _ |a Evans, Alan
|b 22
|e Contributor
700 1 _ |a Gauthier, Claudine
|b 23
|e Contributor
700 1 _ |a Geddes, Maiya R
|b 24
|e Contributor
700 1 _ |a Hoge, Rick
|b 25
|e Contributor
700 1 _ |a Ituria-Medina, Yasser
|b 26
|e Contributor
700 1 _ |a Multhaup, Gerhard
|b 27
|e Contributor
700 1 _ |a Münter, Lisa-Marie
|b 28
|e Contributor
700 1 _ |a Rajah, M Natasha
|b 29
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700 1 _ |a Rosa-Neto, Pedro
|b 30
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700 1 _ |a Schmitz, Taylor
|b 31
|e Contributor
700 1 _ |a Soucy, Jean-Paul
|b 32
|e Contributor
700 1 _ |a Spreng, Nathan
|b 33
|e Contributor
700 1 _ |a Tardif, Christine
|b 34
|e Contributor
700 1 _ |a Vachon-Presseau, Etienne
|b 35
|e Contributor
700 1 _ |a Bocti, Christian
|b 36
|e Contributor
700 1 _ |a Descoteaux, Maxime
|b 37
|e Contributor
700 1 _ |a Laforce, Robert
|b 38
|e Contributor
700 1 _ |a Binette, Alexa Pichet
|b 39
|e Contributor
773 _ _ |a 10.1038/s41598-025-21596-0
|g Vol. 15, no. 1, p. 38499
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