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@ARTICLE{vonRennenberg:281855,
      author       = {von Rennenberg, Regina and Litmeier, Simon and Szabo,
                      Kristina and Mengel, Annerose and Petersen, Martina and
                      Wunderlich, Silke and Michalski, Dominik and Thomalla, Götz
                      and Kallmünzer, Bernd and Petzold, Gabor and Dichgans,
                      Martin and Siepmann, Timo and Royl, Georg and Ringleb, Peter
                      Arthur and Nolte, Christian H and Endres, Matthias},
      title        = {{C}ognitive performance in patients with ischemic stroke
                      and additional myocardial injury - results from the
                      multicenter prospective observational {PRAISE} study.},
      journal      = {Neurological research and practice},
      volume       = {7},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2025-01228},
      pages        = {84},
      year         = {2025},
      abstract     = {In the general population, cognitive impairment and
                      dementia are more common in individuals with prior
                      myocardial injury, defined as elevated levels of
                      high-sensitive cardiac troponin (hs-cTn). In stroke
                      patients, data on the link between myocardial injury and
                      cognitive outcome are scarce. We aimed to analyze the
                      association between the severity of myocardial injury
                      (degree of hs-cTn elevation), presence of acute myocardial
                      injury (dynamic change in elevated hs-cTn values > $20\%$ in
                      serial measurements) and cognitive performance over time
                      after acute ischemic stroke.This is a prespecified analysis
                      of the prospective multicenter observational PRediction of
                      Acute coronary syndrome in acute Ischemic StrokE (PRAISE)
                      study. PRAISE included 254 patients with an acute ischemic
                      stroke or transient ischemic attack (TIA) and myocardial
                      injury in 26 centers in Germany. Patients underwent
                      cognitive assessment at baseline and before hospital
                      discharge using the Montreal Cognitive Assessment (MoCA) and
                      at three and twelve months after the index event using the
                      Telephone Interview for Cognitive Status (TICS). We used
                      linear regression to analyze the associations between
                      cognitive performance and (1) severity of myocardial injury
                      and (2) presence of acute myocardial injury. The association
                      between hs-cTn and TICS scores over time was examined using
                      inverse probability weighted generalized linear
                      models.Severity of myocardial Injury was associated with
                      lower MoCA scores (adjusted beta - 2.6, $95\%$ CI -4.0 -
                      -1.2, p < 0.001) and higher proportion of cognitive
                      impairment (i.e. MoCA score < 26 points) (adjusted OR 2.9,
                      $95\%CI$ 1.3-6.7, p = 0.012). Acute myocardial injury was
                      associated with better cognitive performance (adjusted beta
                      1.8, $95\%$ CI 0.4-3.1, p = 0.011). We found no association
                      between hs-cTn and cognitive decline over twelve months.In
                      patients with ischemic stroke, the severity of myocardial
                      injury in general but not the presence of acute myocardial
                      injury at time of stroke is associated with cognitive
                      impairment.Clinicaltrials.gov NCT03609385
                      $https://clinicaltrials.gov/study/NCT03609385?term=NCT03609385\&rank=1$
                      Date of registration 6th July 2018.},
      cin          = {AG Endres / AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005 / I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41189028},
      doi          = {10.1186/s42466-025-00446-4},
      url          = {https://pub.dzne.de/record/281855},
}