000281859 001__ 281859
000281859 005__ 20251218103439.0
000281859 0247_ $$2doi$$a10.1177/13872877251343296
000281859 0247_ $$2pmid$$apmid:40415342
000281859 0247_ $$2pmc$$apmc:PMC12583645
000281859 0247_ $$2ISSN$$a1387-2877
000281859 0247_ $$2ISSN$$a1875-8908
000281859 037__ $$aDZNE-2025-01232
000281859 041__ $$aEnglish
000281859 082__ $$a610
000281859 1001_ $$00000-0002-7304-0834$$aAlexopoulou, Zampeta-Sofia$$b0
000281859 245__ $$aSpeech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores.
000281859 260__ $$aAmsterdam$$bIOS Press$$c2025
000281859 3367_ $$2DRIVER$$aarticle
000281859 3367_ $$2DataCite$$aOutput Types/Journal article
000281859 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1762358491_31815
000281859 3367_ $$2BibTeX$$aARTICLE
000281859 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000281859 3367_ $$00$$2EndNote$$aJournal Article
000281859 520__ $$aBackgroundCognitive decline in Alzheimer's disease (AD) often includes speech impairments, where subtle changes may precede clinical dementia onset. As clinical trials focus on early identification of patients for disease-modifying treatments, digital speech-based assessments for scalable screening have become crucial.ObjectiveThis study aimed to validate a remote, speech-based digital cognitive assessment for mild cognitive impairment (MCI) detection through the comparison with gold-standard paper-based neurocognitive assessments.MethodsWithin the PROSPECT-AD project, speech and clinical data were obtained from the German DELCODE and DESCRIBE cohorts, including 21 healthy controls (HC), 110 participants with subjective cognitive decline (SCD), and 59 with MCI. Spearman rank and partial correlations were computed between speech-based scores and clinical measures. Kruskal-Wallis tests assessed group differences. We trained machine learning models to classify diagnostic groups comparing classification accuracies between gold-standard assessment scores and a speech-based digital cognitive assessment composite score (SB-C).ResultsGlobal cognition, as measured by SB-C, significantly differed between diagnostic groups (H(2) = 30.93, p < 0.001). Speech-based scores were significantly correlated with global anchor scores (MMSE, CDR, PACC5). Speech-based composites for memory, executive function and processing speed were also correlated with respective domain-specific paper-based assessments. In logistic regression classification, the model combining SB-C and neuropsychological tests at baseline achieved a high discriminatory power in differentiating HC/SCD from MCI patients (Area Under the Curve = 0.86).ConclusionsOur findings support speech-based cognitive assessments as a promising avenue towards remote MCI screening, with implications for scalable screening in clinical trials and healthcare.
000281859 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000281859 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x1
000281859 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000281859 650_7 $$2Other$$aAlzheimer's disease
000281859 650_7 $$2Other$$adementia
000281859 650_7 $$2Other$$adigital cognitive assessment
000281859 650_7 $$2Other$$amild cognitive impairment
000281859 650_7 $$2Other$$aspeech analysis
000281859 650_7 $$2Other$$aspeech-based digital cognitive assessment
000281859 650_7 $$2Other$$aspeech-based markers
000281859 650_2 $$2MeSH$$aHumans
000281859 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000281859 650_2 $$2MeSH$$aCognitive Dysfunction: psychology
000281859 650_2 $$2MeSH$$aMale
000281859 650_2 $$2MeSH$$aFemale
000281859 650_2 $$2MeSH$$aAged
000281859 650_2 $$2MeSH$$aNeuropsychological Tests
000281859 650_2 $$2MeSH$$aSpeech: physiology
000281859 650_2 $$2MeSH$$aAged, 80 and over
000281859 650_2 $$2MeSH$$aMiddle Aged
000281859 650_2 $$2MeSH$$aCohort Studies
000281859 7001_ $$0P:(DE-2719)2811683$$aKöhler, Stefanie$$b1
000281859 7001_ $$aMallick, Elisa$$b2
000281859 7001_ $$00000-0003-3404-0126$$aTröger, Johannes$$b3
000281859 7001_ $$00000-0001-5178-3234$$aLinz, Nicklas$$b4
000281859 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike$$b5
000281859 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b6$$udzne
000281859 7001_ $$0P:(DE-2719)9000444$$aBartels, Claudia$$b7
000281859 7001_ $$00000-0001-5189-134X$$aRostamzadeh, Ayda$$b8
000281859 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b9
000281859 7001_ $$0P:(DE-2719)9001517$$aIncesoy, Enise I$$b10
000281859 7001_ $$0P:(DE-2719)9001011$$aButryn, Michaela$$b11$$udzne
000281859 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b12
000281859 7001_ $$0P:(DE-2719)9003152$$aSodenkamp, Sebastian$$b13
000281859 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias Hj$$b14
000281859 7001_ $$0P:(DE-2719)2810905$$aOsterrath, Antje$$b15
000281859 7001_ $$0P:(DE-2719)9002699$$aEsser, Anna$$b16$$udzne
000281859 7001_ $$0P:(DE-2719)2810395$$aRoeske, Sandra$$b17
000281859 7001_ $$0P:(DE-2719)2810481$$aFrommann, Ingo$$b18
000281859 7001_ $$0P:(DE-2719)9001773$$aStark, Melina$$b19
000281859 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b20
000281859 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b21
000281859 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b22
000281859 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b23$$udzne
000281859 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b24
000281859 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b25$$udzne
000281859 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b26$$udzne
000281859 7001_ $$0P:(DE-2719)2814178$$aFalkenburger, Bjoern$$b27
000281859 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b28
000281859 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b29$$udzne
000281859 7001_ $$00000-0003-4490-4485$$aManera, Valeria$$b30
000281859 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b31
000281859 7001_ $$00000-0001-9960-9657$$aKönig, Alexandra$$b32
000281859 773__ $$0PERI:(DE-600)2070772-1$$a10.1177/13872877251343296$$gVol. 108, no. 1_suppl$$n1_suppl$$pS118 - S131$$tJournal of Alzheimer's disease$$v108$$x1387-2877$$y2025
000281859 8564_ $$uhttps://pub.dzne.de/record/281859/files/DZNE-2025-01232.pdf$$yOpenAccess
000281859 8564_ $$uhttps://pub.dzne.de/record/281859/files/DZNE-2025-01232.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000281859 909CO $$ooai:pub.dzne.de:281859$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811683$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812446$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811326$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811614$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001517$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001011$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b11$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810394$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9003152$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001516$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810905$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002699$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b16$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810395$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b17$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810481$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b18$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001773$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b19$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812139$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b20$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811324$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b21$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811122$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b22$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812035$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b23$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811317$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b24$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000032$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b25$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000005$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b26$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814178$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b27$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000057$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b28$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000055$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b29$$kDZNE
000281859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000026$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b31$$kDZNE
000281859 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000281859 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x1
000281859 9141_ $$y2025
000281859 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-20
000281859 915__ $$0LIC:(DE-HGF)CCBYNC4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial CC BY-NC 4.0
000281859 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000281859 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-20
000281859 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-20
000281859 9201_ $$0I:(DE-2719)1510100$$kAG Teipel$$lClinical Dementia Research (Rostock /Greifswald)$$x0
000281859 9201_ $$0I:(DE-2719)5000007$$kAG Priller$$lTranslational Neuropsychiatry$$x1
000281859 9201_ $$0I:(DE-2719)1011101$$kPatient Studies (Bonn)$$lPatient Studies (Bonn)$$x2
000281859 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x3
000281859 9201_ $$0I:(DE-2719)1240005$$kICRU$$lCore ICRU$$x4
000281859 9201_ $$0I:(DE-2719)1210000$$kAG Gasser$$lParkinson Genetics$$x5
000281859 9201_ $$0I:(DE-2719)1710012$$kAG Falkenburger$$lTranslational Parkinson Research$$x6
000281859 9201_ $$0I:(DE-2719)1011103$$kAG Spottke$$lClinical Research Platform (CRP)$$x7
000281859 9201_ $$0I:(DE-2719)1011201$$kAG Wagner$$lNeuropsychology$$x8
000281859 9201_ $$0I:(DE-2719)1011401$$kClinical Research Platform (CRP)$$lClinical Research Platform (CRP)$$x9
000281859 9201_ $$0I:(DE-2719)1011305$$kAG Schneider$$lTranslational Dementia Research (Bonn)$$x10
000281859 9201_ $$0I:(DE-2719)1410006$$kAG Wiltfang$$lMolecular biomarkers for predictive diagnostics of neurodegenerative diseases$$x11
000281859 9201_ $$0I:(DE-2719)1011102$$kAG Jessen$$lClinical Alzheimer’s Disease Research$$x12
000281859 980__ $$ajournal
000281859 980__ $$aVDB
000281859 980__ $$aUNRESTRICTED
000281859 980__ $$aI:(DE-2719)1510100
000281859 980__ $$aI:(DE-2719)5000007
000281859 980__ $$aI:(DE-2719)1011101
000281859 980__ $$aI:(DE-2719)5000006
000281859 980__ $$aI:(DE-2719)1240005
000281859 980__ $$aI:(DE-2719)1210000
000281859 980__ $$aI:(DE-2719)1710012
000281859 980__ $$aI:(DE-2719)1011103
000281859 980__ $$aI:(DE-2719)1011201
000281859 980__ $$aI:(DE-2719)1011401
000281859 980__ $$aI:(DE-2719)1011305
000281859 980__ $$aI:(DE-2719)1410006
000281859 980__ $$aI:(DE-2719)1011102
000281859 9801_ $$aFullTexts