Home > Publications Database > Hippocampal Commissural Circuitry Shows Asymmetric cAMP-Dependent Synaptic Plasticity. > print

001     281864
005     20251128103126.0
024 7 _ |a 10.1021/acschemneuro.5c00454
|2 doi
024 7 _ |a pmid:41081426
|2 pmid
037 _ _ |a DZNE-2025-01237
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Faiß, Lukas
|0 P:(DE-2719)9001061
|b 0
|e First author
|u dzne
245 _ _ |a Hippocampal Commissural Circuitry Shows Asymmetric cAMP-Dependent Synaptic Plasticity.
260 _ _ |a Washington, DC
|c 2025
|b ACS Publ.
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1764248866_8030
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Hemispheric asymmetries in NMDAR-dependent synaptic plasticity have been described in hippocampal area CA1, but it remains unclear whether similar lateralized mechanisms exist for cyclic adenosine monophosphate (cAMP)-dependent plasticity. Here, we investigated whether cAMP-mediated potentiation of synaptic transmission in mouse CA1 exhibits hemisphere-specific properties. In recordings with electrical stimulation of CA1 inputs, a subset of recordings in the left, but not in the right hemisphere CA1, exhibited a pronounced cAMP-induced potentiation of field excitatory postsynaptic potentials (fEPSPs). To isolate input-specific contributions, we expressed the optogenetic actuator ChrimsonR unilaterally in the CA3/CA2 region of wild-type mice. Light-evoked glutamate release from ipsilateral Schaffer collaterals showed no cAMP sensitivity in either hemisphere, while commissures originating from the right (COR) exhibited cAMP-mediated potentiation of transmission in a subset of experiments. Notably, this effect was absent at commissures originating from the left (COL). The selective presence of the effect prompted us to further investigate the underlying cell population using CA3-specific (G32-4 Cre) and CA2-specific (Amigo2-Cre) driver lines. Recordings from synapses of CA3 COR recapitulated the cAMP-induced potentiation of transmitter release observed in wild-type animals. However, the effect was again restricted to a subset of experiments, did not correlate with the age or the sex of the mice, and was absent in recordings with specific stimulation of CA2 COR. Our results demonstrate a variable cAMP sensitivity of synaptic transmission at COR synapses in the left CA1. Altogether, we reveal a hemisphere-specific cAMP-mediated synaptic plasticity at CA3 COR onto CA1, underscoring hidden heterogeneity and lateralization in hippocampal circuit function.
536 _ _ |a 351 - Brain Function (POF4-351)
|0 G:(DE-HGF)POF4-351
|c POF4-351
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a cAMP
|2 Other
650 _ 7 |a commissural fibers
|2 Other
650 _ 7 |a hippocampus
|2 Other
650 _ 7 |a lateralization
|2 Other
650 _ 7 |a synaptic plasticity
|2 Other
650 _ 7 |a Cyclic AMP
|0 E0399OZS9N
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
650 _ 2 |a Cyclic AMP: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Excitatory Postsynaptic Potentials: physiology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a CA1 Region, Hippocampal: physiology
|2 MeSH
650 _ 2 |a CA1 Region, Hippocampal: metabolism
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Synaptic Transmission: physiology
|2 MeSH
650 _ 2 |a CA3 Region, Hippocampal: physiology
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Functional Laterality: physiology
|2 MeSH
700 1 _ |a Salivara, Aikaterini
|0 P:(DE-2719)9002461
|b 1
|u dzne
700 1 _ |a Oldani, Silvia
|b 2
700 1 _ |a Breustedt, Jörg
|b 3
700 1 _ |a Schmitz, Dietmar
|0 P:(DE-2719)2810725
|b 4
|u dzne
700 1 _ |a Rost, Benjamin R
|0 P:(DE-2719)2810914
|b 5
|e Last author
|u dzne
773 _ _ |a 10.1021/acschemneuro.5c00454
|g Vol. 16, no. 21, p. 4236 - 4245
|0 PERI:(DE-600)2528493-9
|n 21
|p 4236 - 4245
|t ACS chemical neuroscience
|v 16
|y 2025
|x 1948-7193
856 4 _ |u https://pub.dzne.de/record/281864/files/DZNE-2025-01237%20SUP.pdf
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/281864/files/DZNE-2025-01237.pdf
856 4 _ |x pdfa
|u https://pub.dzne.de/record/281864/files/DZNE-2025-01237%20SUP.pdf?subformat=pdfa
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/281864/files/DZNE-2025-01237.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:281864
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)9001061
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)9002461
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 4
|6 P:(DE-2719)2810725
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 5
|6 P:(DE-2719)2810914
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-351
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Brain Function
|x 0
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-14
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b ACS CHEM NEUROSCI : 2022
|d 2024-12-14
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-14
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b ACS CHEM NEUROSCI : 2022
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-14
920 1 _ |0 I:(DE-2719)1810004
|k AG Schmitz
|l Network Dysfunction
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1810004
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21