TY  - JOUR
AU  - Giesers, Naomi K
AU  - Schaeff, Viktoria
AU  - Gertz, Karen
AU  - Endres, Matthias
AU  - Liman, Thomas G
TI  - Associations of Soluble Inflammatory and Endothelial Activation Biomarkers with Cognitive Function Over Three Years After Ischemic Stroke-PROSCIS-B.
JO  - Translational stroke research
VL  - 16
IS  - 6
SN  - 1868-4483
CY  - New York, NY
PB  - Springer
M1  - DZNE-2025-01238
SP  - 2249 - 2257
PY  - 2025
AB  - Vascular inflammation is involved in the pathophysiology of post-stroke cognitive impairment. We aimed to assess whether blood-based biomarkers of inflammation and endothelial dysfunction, such as interleukin 6 (IL-6), vascular cell adhesion molecule (VCAM-1), and tumor necrosis factor-alpha (TNF-α), are associated with cognitive function over time in a prospective cohort of first-ever ischemic stroke patients. Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Cognitive function was assessed with the Telephone Interview for Cognitive Status-modified (TICS-m) at 1 to 3 years of follow-up. Associations of baseline levels of IL-6, VCAM-1, and TNF-α with cognitive function over time were estimated using a linear mixed model adjusted for demographics, education, vascular risk factors, stroke severity, ischemic stroke subtype, and severity of white matter hyperintensity. We included 570 patients with mild-to-moderate ischemic stroke and baseline data on biomarker levels. The mean age was 67 (± 12 SD), 38.6
KW  - Humans
KW  - Female
KW  - Male
KW  - Aged
KW  - Biomarkers: blood
KW  - Ischemic Stroke: blood
KW  - Ischemic Stroke: complications
KW  - Ischemic Stroke: psychology
KW  - Middle Aged
KW  - Vascular Cell Adhesion Molecule-1: blood
KW  - Interleukin-6: blood
KW  - Prospective Studies
KW  - Inflammation: blood
KW  - Cognition: physiology
KW  - Cognitive Dysfunction: blood
KW  - Cognitive Dysfunction: etiology
KW  - Tumor Necrosis Factor-alpha: blood
KW  - Follow-Up Studies
KW  - Endothelial dysfunction (Other)
KW  - Inflammation (Other)
KW  - Ischemic stroke (Other)
KW  - Post stroke cognitive impairment (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Vascular Cell Adhesion Molecule-1 (NLM Chemicals)
KW  - Interleukin-6 (NLM Chemicals)
KW  - Tumor Necrosis Factor-alpha (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41057606
DO  - DOI:10.1007/s12975-025-01388-4
UR  - https://pub.dzne.de/record/281867
ER  -