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| 001 | 281867 | ||
| 005 | 20251127141341.0 | ||
| 024 | 7 | _ | |a 10.1007/s12975-025-01388-4 |2 doi |
| 024 | 7 | _ | |a pmid:41057606 |2 pmid |
| 024 | 7 | _ | |a 1868-4483 |2 ISSN |
| 024 | 7 | _ | |a 1868-601X |2 ISSN |
| 037 | _ | _ | |a DZNE-2025-01238 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Giesers, Naomi K |b 0 |
| 245 | _ | _ | |a Associations of Soluble Inflammatory and Endothelial Activation Biomarkers with Cognitive Function Over Three Years After Ischemic Stroke-PROSCIS-B. |
| 260 | _ | _ | |a New York, NY |c 2025 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1764249099_8032 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Vascular inflammation is involved in the pathophysiology of post-stroke cognitive impairment. We aimed to assess whether blood-based biomarkers of inflammation and endothelial dysfunction, such as interleukin 6 (IL-6), vascular cell adhesion molecule (VCAM-1), and tumor necrosis factor-alpha (TNF-α), are associated with cognitive function over time in a prospective cohort of first-ever ischemic stroke patients. Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Cognitive function was assessed with the Telephone Interview for Cognitive Status-modified (TICS-m) at 1 to 3 years of follow-up. Associations of baseline levels of IL-6, VCAM-1, and TNF-α with cognitive function over time were estimated using a linear mixed model adjusted for demographics, education, vascular risk factors, stroke severity, ischemic stroke subtype, and severity of white matter hyperintensity. We included 570 patients with mild-to-moderate ischemic stroke and baseline data on biomarker levels. The mean age was 67 (± 12 SD), 38.6% were female, and the median National Institutes of Health Stroke Scale (NIHSS) was 2 (IQR 1-4). Frequency of cognitive impairment defined as TICS-m score ≤ 31 was 21.9% at year one, 15.4% at year two, and 11.6% at year three. Higher log-transformed levels of IL-6 and VCAM-1 were associated with lower TICS-m scores over time in the adjusted linear mixed model including white matter hyperintensity burden (IL-6: β = -2.0, 95% CI -3.3 to -0.7, p = 0.003; VCAM-1: β = -4.1, 95% CI -7.3 to -1.0, p = 0.01). In patients with mild-to-moderate first-ever ischemic stroke, higher baseline levels of IL-6 and VCAM-1 were associated with lower Telephone Interview for Cognitive Status-modified during 3 years of follow-up.ClinicalTrials.gov Identifier: NCT01363856. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Endothelial dysfunction |2 Other |
| 650 | _ | 7 | |a Inflammation |2 Other |
| 650 | _ | 7 | |a Ischemic stroke |2 Other |
| 650 | _ | 7 | |a Post stroke cognitive impairment |2 Other |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 7 | |a Vascular Cell Adhesion Molecule-1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Interleukin-6 |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Necrosis Factor-alpha |2 NLM Chemicals |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Biomarkers: blood |2 MeSH |
| 650 | _ | 2 | |a Ischemic Stroke: blood |2 MeSH |
| 650 | _ | 2 | |a Ischemic Stroke: complications |2 MeSH |
| 650 | _ | 2 | |a Ischemic Stroke: psychology |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Vascular Cell Adhesion Molecule-1: blood |2 MeSH |
| 650 | _ | 2 | |a Interleukin-6: blood |2 MeSH |
| 650 | _ | 2 | |a Prospective Studies |2 MeSH |
| 650 | _ | 2 | |a Inflammation: blood |2 MeSH |
| 650 | _ | 2 | |a Cognition: physiology |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: blood |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: etiology |2 MeSH |
| 650 | _ | 2 | |a Tumor Necrosis Factor-alpha: blood |2 MeSH |
| 650 | _ | 2 | |a Follow-Up Studies |2 MeSH |
| 700 | 1 | _ | |a Schaeff, Viktoria |b 1 |
| 700 | 1 | _ | |a Gertz, Karen |b 2 |
| 700 | 1 | _ | |a Endres, Matthias |0 P:(DE-2719)2811033 |b 3 |u dzne |
| 700 | 1 | _ | |a Liman, Thomas G |0 P:(DE-2719)9000189 |b 4 |e Last author |u dzne |
| 773 | _ | _ | |a 10.1007/s12975-025-01388-4 |g Vol. 16, no. 6, p. 2249 - 2257 |0 PERI:(DE-600)2541897-X |n 6 |p 2249 - 2257 |t Translational stroke research |v 16 |y 2025 |x 1868-4483 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/281867/files/DZNE-2025-01238%20SUP.docx |
| 856 | 4 | _ | |u https://pub.dzne.de/record/281867/files/DZNE-2025-01238.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/281867/files/DZNE-2025-01238%20SUP.doc |
| 856 | 4 | _ | |u https://pub.dzne.de/record/281867/files/DZNE-2025-01238%20SUP.odt |
| 856 | 4 | _ | |u https://pub.dzne.de/record/281867/files/DZNE-2025-01238%20SUP.pdf |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)2811033 |
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