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000281870 037__ $$aDZNE-2025-01241
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000281870 1001_ $$aParveen, Kayenat$$b0
000281870 245__ $$aProgression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.
000281870 260__ $$aAmsterdam$$bIOS Press$$c2025
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000281870 520__ $$aParkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.
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000281870 650_7 $$2Other$$aAlzheimer's disease
000281870 650_7 $$2Other$$aParkinson's disease
000281870 650_7 $$2Other$$agenome-wide association study
000281870 650_7 $$2Other$$amild cognitive impairment
000281870 650_7 $$2Other$$asingle nucleotide polymorphism
000281870 650_2 $$2MeSH$$aHumans
000281870 650_2 $$2MeSH$$aParkinson Disease: genetics
000281870 650_2 $$2MeSH$$aParkinson Disease: complications
000281870 650_2 $$2MeSH$$aGenome-Wide Association Study
000281870 650_2 $$2MeSH$$aMale
000281870 650_2 $$2MeSH$$aAged
000281870 650_2 $$2MeSH$$aFemale
000281870 650_2 $$2MeSH$$aDisease Progression
000281870 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000281870 650_2 $$2MeSH$$aCognitive Dysfunction: etiology
000281870 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000281870 650_2 $$2MeSH$$aDementia: genetics
000281870 650_2 $$2MeSH$$aDementia: etiology
000281870 650_2 $$2MeSH$$aMiddle Aged
000281870 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000281870 650_2 $$2MeSH$$aMultifactorial Inheritance
000281870 7001_ $$00000-0001-9286-2748$$aRoss, J Alexander$$b1
000281870 7001_ $$00000-0002-1044-417X$$avan der Wurp, Hendrik$$b2
000281870 7001_ $$aBalzer-Geldsetzer, Monika$$b3
000281870 7001_ $$0P:(DE-2719)2000059$$aBerg, Daniela$$b4
000281870 7001_ $$0P:(DE-2719)9000934$$aDeuschl, Günther$$b5
000281870 7001_ $$0P:(DE-2719)2320009$$aGasser, Thomas$$b6
000281870 7001_ $$aHilker-Roggendorf, Rüdiger$$b7
000281870 7001_ $$00000-0001-8603-2545$$aKalbe, Elke$$b8
000281870 7001_ $$0P:(DE-2719)2109499$$aLiepelt-Scarfone, Inga$$b9$$udzne
000281870 7001_ $$0P:(DE-2719)9001340$$aMollenhauer, Brit$$b10$$udzne
000281870 7001_ $$00000-0002-1721-502X$$aRiedel, Oliver$$b11
000281870 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b12
000281870 7001_ $$00000-0002-8903-0593$$aSchulz, Jörg B$$b13
000281870 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b14
000281870 7001_ $$0P:(DE-2719)9000306$$aStorch, Alexander$$b15
000281870 7001_ $$00000-0001-6407-1199$$aTrenkwalder, Claudia$$b16
000281870 7001_ $$0P:(DE-2719)9001967$$aKassubek, Jan$$b17
000281870 7001_ $$aWitt, Karsten$$b18
000281870 7001_ $$0P:(DE-2719)9000057$$aDodel, Richard$$b19
000281870 7001_ $$0P:(DE-2719)2000056$$aWüllner, Ullrich$$b20
000281870 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b21
000281870 7001_ $$00000-0002-4901-9955$$aDalmasso, Maria Carolina$$b22
000281870 773__ $$0PERI:(DE-600)2599550-9$$a10.1177/1877718X251356512$$gVol. 15, no. 7, p. 1304 - 1311$$n7$$p1304 - 1311$$tJournal of Parkinson's Disease$$v15$$x1877-7171$$y2025
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