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@ARTICLE{Parveen:281870,
      author       = {Parveen, Kayenat and Ross, J Alexander and van der Wurp,
                      Hendrik and Balzer-Geldsetzer, Monika and Berg, Daniela and
                      Deuschl, Günther and Gasser, Thomas and Hilker-Roggendorf,
                      Rüdiger and Kalbe, Elke and Liepelt-Scarfone, Inga and
                      Mollenhauer, Brit and Riedel, Oliver and Röske, Sandra and
                      Schulz, Jörg B and Spottke, Annika and Storch, Alexander
                      and Trenkwalder, Claudia and Kassubek, Jan and Witt, Karsten
                      and Dodel, Richard and Wüllner, Ullrich and Ramirez,
                      Alfredo and Dalmasso, Maria Carolina},
      title        = {{P}rogression to {P}arkinson's dementia is not modulated by
                      genetic risk variants for {A}lzheimer's or {P}arkinson's
                      disease.},
      journal      = {Journal of Parkinson's Disease},
      volume       = {15},
      number       = {7},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2025-01241},
      pages        = {1304 - 1311},
      year         = {2025},
      abstract     = {Parkinson's disease (PD) is marked by motor symptoms and
                      often accompanied by mild cognitive impairment (PD-MCI),
                      affecting up to $50\%$ of patients and preceding PD dementia
                      (PDD). Genetic factors may influence this progression, yet
                      the underlying mechanisms remain unclear. This study
                      investigated genetic factors influencing the progression
                      from PD-MCI to PDD using polygenic risk scores (PRS). A
                      genome-wide association study (GWAS) was conducted using
                      data from the LANDSCAPE study. Multivariable Cox regression,
                      Kaplan-Meier survival analysis, and concordance statistics
                      assessed the relationship between PRS and PDD progression.
                      No significant association was found between PD PRS and the
                      risk of developing PDD.},
      keywords     = {Humans / Parkinson Disease: genetics / Parkinson Disease:
                      complications / Genome-Wide Association Study / Male / Aged
                      / Female / Disease Progression / Cognitive Dysfunction:
                      genetics / Cognitive Dysfunction: etiology / Alzheimer
                      Disease: genetics / Dementia: genetics / Dementia: etiology
                      / Middle Aged / Genetic Predisposition to Disease /
                      Multifactorial Inheritance / Alzheimer's disease (Other) /
                      Parkinson's disease (Other) / genome-wide association study
                      (Other) / mild cognitive impairment (Other) / single
                      nucleotide polymorphism (Other)},
      cin          = {AG Gasser / AG Wagner / AG Spottke / Clinical Research
                      Platform (CRP) / AG Storch / Clinical Study Center (Ulm) /
                      AG Wüllner / Patient Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)1011201 /
                      I:(DE-2719)1011103 / I:(DE-2719)1011401 / I:(DE-2719)5000014
                      / I:(DE-2719)5000077 / I:(DE-2719)1011302 /
                      I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40739885},
      doi          = {10.1177/1877718X251356512},
      url          = {https://pub.dzne.de/record/281870},
}