Home > Publications Database > Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease. > print

001     281870
005     20251127141829.0
024 7 _ |a 10.1177/1877718X251356512
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024 7 _ |a 1877-7171
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024 7 _ |a 1877-718X
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037 _ _ |a DZNE-2025-01241
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Parveen, Kayenat
|b 0
245 _ _ |a Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.
260 _ _ |a Amsterdam
|c 2025
|b IOS Press
336 7 _ |a article
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520 _ _ |a Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.
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650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a Parkinson's disease
|2 Other
650 _ 7 |a genome-wide association study
|2 Other
650 _ 7 |a mild cognitive impairment
|2 Other
650 _ 7 |a single nucleotide polymorphism
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Parkinson Disease: genetics
|2 MeSH
650 _ 2 |a Parkinson Disease: complications
|2 MeSH
650 _ 2 |a Genome-Wide Association Study
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Disease Progression
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: genetics
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: etiology
|2 MeSH
650 _ 2 |a Alzheimer Disease: genetics
|2 MeSH
650 _ 2 |a Dementia: genetics
|2 MeSH
650 _ 2 |a Dementia: etiology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Genetic Predisposition to Disease
|2 MeSH
650 _ 2 |a Multifactorial Inheritance
|2 MeSH
700 1 _ |a Ross, J Alexander
|0 0000-0001-9286-2748
|b 1
700 1 _ |a van der Wurp, Hendrik
|0 0000-0002-1044-417X
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700 1 _ |a Balzer-Geldsetzer, Monika
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700 1 _ |a Berg, Daniela
|0 P:(DE-2719)2000059
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700 1 _ |a Deuschl, Günther
|0 P:(DE-2719)9000934
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700 1 _ |a Gasser, Thomas
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700 1 _ |a Hilker-Roggendorf, Rüdiger
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700 1 _ |a Kalbe, Elke
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700 1 _ |a Liepelt-Scarfone, Inga
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700 1 _ |a Mollenhauer, Brit
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700 1 _ |a Riedel, Oliver
|0 0000-0002-1721-502X
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700 1 _ |a Röske, Sandra
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700 1 _ |a Schulz, Jörg B
|0 0000-0002-8903-0593
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700 1 _ |a Spottke, Annika
|0 P:(DE-2719)2811324
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700 1 _ |a Storch, Alexander
|0 P:(DE-2719)9000306
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700 1 _ |a Trenkwalder, Claudia
|0 0000-0001-6407-1199
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700 1 _ |a Kassubek, Jan
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700 1 _ |a Witt, Karsten
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700 1 _ |a Dodel, Richard
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700 1 _ |a Wüllner, Ullrich
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700 1 _ |a Ramirez, Alfredo
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700 1 _ |a Dalmasso, Maria Carolina
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773 _ _ |a 10.1177/1877718X251356512
|g Vol. 15, no. 7, p. 1304 - 1311
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|t Journal of Parkinson's Disease
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