%0 Journal Article
%A de Bruin, Hannah
%A Groot, Colin
%A Barthel, Henryk
%A Bischof, Gérard N
%A Blazhenets, Ganna
%A Boellaard, Ronald
%A Boon, Baayla D C
%A Brendel, Matthias
%A Cash, David M
%A Coath, William
%A Day, Gregory S
%A Dickerson, Bradford C
%A Doering, Elena
%A Drzezga, Alexander
%A van Dyck, Christopher H
%A Eimeren, Thilo
%A van der Flier, Wiesje M
%A Fredericks, Carolyn A
%A Fryer, Tim D
%A van de Giessen, Elsmarieke
%A Gordon, Brian A
%A Graff-Radford, Jonathan
%A Grinberg, Lea T
%A Hansson, Oskar
%A Hobbs, Diana A
%A Hoenig, Merle C
%A Höglinger, Günter
%A Irwin, David J
%A Jones, P Simon
%A Josephs, Keith A
%A Katsumi, Yuta
%A La Joie, Renaud
%A Lee, Edward B
%A Levin, Johannes
%A Malpetti, Maura
%A McGinnis, Scott M
%A Mecca, Adam P
%A Mohanty, Rosaleena
%A Nasrallah, Ilya M
%A O'Brien, John T
%A O'Dell, Ryan S
%A Palleis, Carla
%A Perneczky, Robert
%A Phillips, Jeffrey S
%A Putcha, Deepti
%A Rabinovici, Gil D
%A Rahmouni, Nesrine
%A Rosa-Neto, Pedro
%A Rowe, James B
%A Rullmann, Michael
%A Sabri, Osama
%A Saur, Dorothee
%A Schildan, Andreas
%A Schott, Jonathan M
%A Schroeter, Matthias L
%A Seeley, William W
%A Servaes, Stijn
%A Sintini, Irene
%A Smith, Ruben
%A Spina, Salvatore
%A Stevenson, Jenna
%A Stomrud, Erik
%A Strandberg, Olof
%A Therriault, Joseph
%A Tideman, Pontus
%A Touroutoglou, Alexandra
%A Trainer, Anne E
%A Visser, Denise
%A Wekselman, Fattin
%A Weston, Philip S J
%A Whitwell, Jennifer L
%A Wolk, David A
%A Yong, Keir
%A Pijnenburg, Yolande A L
%A Franzmeier, Nicolai
%A Ossenkoppele, Rik
%T Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease.
%J Brain
%V 148
%N 11
%@ 0006-8950
%C Oxford
%I Oxford Univ. Press
%M DZNE-2025-01246
%P 3893 - 3912
%D 2025
%X The link between regional tau load and clinical manifestation of Alzheimer's disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progression of tau pathology mirrors the functional connections from temporal lobe epicentres. However, given the limited spatial heterogeneity of tau in typical AD, atypical (non-amnestic-predominant) AD variants with distinct tau patterns provide a key opportunity to investigate the universality of connectivity as a scaffold for tau progression. In this large-scale, multicentre study across 14 international sites, we included cross-sectional tau-PET data from 320 individuals with atypical AD (n = 139 posterior cortical atrophy/PCA-AD; n = 103 logopenic variant primary progressive aphasia/lvPPA-AD; n = 35 behavioural variant AD/bvAD; n = 43 corticobasal syndrome/CBS-AD), with a subset of individuals (n = 78) having longitudinal tau-PET data. Additionally, as an independent sample, we included regional post-mortem tau stainings from 93 atypical AD patients from two sites (n = 19 PCA-AD, n = 32 lvPPA-AD, n = 23 bvAD, n = 19 CBS-AD). Gaussian mixture modelling was used to harmonize different tau-PET tracers by transforming tau-PET standardized uptake value ratios to tau positivity probabilities (a uniform scale ranging from 0
%K Humans
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: metabolism
%K Alzheimer Disease: pathology
%K Female
%K Male
%K Disease Progression
%K Aged
%K tau Proteins: metabolism
%K Positron-Emission Tomography
%K Cross-Sectional Studies
%K Middle Aged
%K Aged, 80 and over
%K Brain: diagnostic imaging
%K Brain: metabolism
%K Brain: pathology
%K Magnetic Resonance Imaging
%K Longitudinal Studies
%K PET (Other)
%K atypical Alzheimer's disease (Other)
%K connectivity (Other)
%K fMRI (Other)
%K heterogeneity (Other)
%K tau (Other)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40810361
%2 pmc:PMC12588720
%R 10.1093/brain/awaf279
%U https://pub.dzne.de/record/281875