TY  - JOUR
AU  - de Bruin, Hannah
AU  - Groot, Colin
AU  - Barthel, Henryk
AU  - Bischof, Gérard N
AU  - Blazhenets, Ganna
AU  - Boellaard, Ronald
AU  - Boon, Baayla D C
AU  - Brendel, Matthias
AU  - Cash, David M
AU  - Coath, William
AU  - Day, Gregory S
AU  - Dickerson, Bradford C
AU  - Doering, Elena
AU  - Drzezga, Alexander
AU  - van Dyck, Christopher H
AU  - Eimeren, Thilo
AU  - van der Flier, Wiesje M
AU  - Fredericks, Carolyn A
AU  - Fryer, Tim D
AU  - van de Giessen, Elsmarieke
AU  - Gordon, Brian A
AU  - Graff-Radford, Jonathan
AU  - Grinberg, Lea T
AU  - Hansson, Oskar
AU  - Hobbs, Diana A
AU  - Hoenig, Merle C
AU  - Höglinger, Günter
AU  - Irwin, David J
AU  - Jones, P Simon
AU  - Josephs, Keith A
AU  - Katsumi, Yuta
AU  - La Joie, Renaud
AU  - Lee, Edward B
AU  - Levin, Johannes
AU  - Malpetti, Maura
AU  - McGinnis, Scott M
AU  - Mecca, Adam P
AU  - Mohanty, Rosaleena
AU  - Nasrallah, Ilya M
AU  - O'Brien, John T
AU  - O'Dell, Ryan S
AU  - Palleis, Carla
AU  - Perneczky, Robert
AU  - Phillips, Jeffrey S
AU  - Putcha, Deepti
AU  - Rabinovici, Gil D
AU  - Rahmouni, Nesrine
AU  - Rosa-Neto, Pedro
AU  - Rowe, James B
AU  - Rullmann, Michael
AU  - Sabri, Osama
AU  - Saur, Dorothee
AU  - Schildan, Andreas
AU  - Schott, Jonathan M
AU  - Schroeter, Matthias L
AU  - Seeley, William W
AU  - Servaes, Stijn
AU  - Sintini, Irene
AU  - Smith, Ruben
AU  - Spina, Salvatore
AU  - Stevenson, Jenna
AU  - Stomrud, Erik
AU  - Strandberg, Olof
AU  - Therriault, Joseph
AU  - Tideman, Pontus
AU  - Touroutoglou, Alexandra
AU  - Trainer, Anne E
AU  - Visser, Denise
AU  - Wekselman, Fattin
AU  - Weston, Philip S J
AU  - Whitwell, Jennifer L
AU  - Wolk, David A
AU  - Yong, Keir
AU  - Pijnenburg, Yolande A L
AU  - Franzmeier, Nicolai
AU  - Ossenkoppele, Rik
TI  - Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease.
JO  - Brain
VL  - 148
IS  - 11
SN  - 0006-8950
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2025-01246
SP  - 3893 - 3912
PY  - 2025
AB  - The link between regional tau load and clinical manifestation of Alzheimer's disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progression of tau pathology mirrors the functional connections from temporal lobe epicentres. However, given the limited spatial heterogeneity of tau in typical AD, atypical (non-amnestic-predominant) AD variants with distinct tau patterns provide a key opportunity to investigate the universality of connectivity as a scaffold for tau progression. In this large-scale, multicentre study across 14 international sites, we included cross-sectional tau-PET data from 320 individuals with atypical AD (n = 139 posterior cortical atrophy/PCA-AD; n = 103 logopenic variant primary progressive aphasia/lvPPA-AD; n = 35 behavioural variant AD/bvAD; n = 43 corticobasal syndrome/CBS-AD), with a subset of individuals (n = 78) having longitudinal tau-PET data. Additionally, as an independent sample, we included regional post-mortem tau stainings from 93 atypical AD patients from two sites (n = 19 PCA-AD, n = 32 lvPPA-AD, n = 23 bvAD, n = 19 CBS-AD). Gaussian mixture modelling was used to harmonize different tau-PET tracers by transforming tau-PET standardized uptake value ratios to tau positivity probabilities (a uniform scale ranging from 0
KW  - Humans
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: pathology
KW  - Female
KW  - Male
KW  - Disease Progression
KW  - Aged
KW  - tau Proteins: metabolism
KW  - Positron-Emission Tomography
KW  - Cross-Sectional Studies
KW  - Middle Aged
KW  - Aged, 80 and over
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Brain: pathology
KW  - Magnetic Resonance Imaging
KW  - Longitudinal Studies
KW  - PET (Other)
KW  - atypical Alzheimer's disease (Other)
KW  - connectivity (Other)
KW  - fMRI (Other)
KW  - heterogeneity (Other)
KW  - tau (Other)
KW  - tau Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40810361
C2  - pmc:PMC12588720
DO  - DOI:10.1093/brain/awaf279
UR  - https://pub.dzne.de/record/281875
ER  -