%0 Journal Article
%A Garza, Alejandra P
%A Morton, Lorena
%A Motsch, Anna-Lena
%A Puta, Christian
%A Stiebler, Marvin
%A Lading, Yves
%A Chakrabarty, Sabyasachi
%A Schreiber, Stefanie
%A Buzás, Edit I
%A Braun-Dullaeus, Rüdiger
%A Müller, Patrick
%A Dunay, Ildiko R
%T Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention.
%J Frontiers in immunology
%V 16
%@ 1664-3224
%C Lausanne
%I Frontiers Media
%M DZNE-2025-01250
%P 1661161
%D 2025
%X Aging is accompanied by immunoscenescence and chronic low-grade inflammation (inflammaging), contributing to age-related diseases. Physical exercise is a potent modulator of immune function and systemic inflammation, yet the effects of acute exercise intensity on immune activation, cytokine dynamics, and extracellular vesicle release in older adults remain incompletely characterized, particularly in a sex-specific context. This study investigated how a single session of acute continuous moderate versus intense exercise modulates immune cell subsets, cytokine levels, and EV profiles in healthy older individuals, with emphasis on sex-based differences.Thirty-three older adults completed either a moderate (n=14, 54-79 years; 60
%K cardiovascular fitness (Other)
%K extracellular vesicles (Other)
%K healthy aging (Other)
%K inflammaging (Other)
%K sex differences (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41208983
%2 pmc:PMC12591881
%R 10.3389/fimmu.2025.1661161
%U https://pub.dzne.de/record/281879