TY  - JOUR
AU  - Garza, Alejandra P
AU  - Morton, Lorena
AU  - Motsch, Anna-Lena
AU  - Puta, Christian
AU  - Stiebler, Marvin
AU  - Lading, Yves
AU  - Chakrabarty, Sabyasachi
AU  - Schreiber, Stefanie
AU  - Buzás, Edit I
AU  - Braun-Dullaeus, Rüdiger
AU  - Müller, Patrick
AU  - Dunay, Ildiko R
TI  - Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention.
JO  - Frontiers in immunology
VL  - 16
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2025-01250
SP  - 1661161
PY  - 2025
AB  - Aging is accompanied by immunoscenescence and chronic low-grade inflammation (inflammaging), contributing to age-related diseases. Physical exercise is a potent modulator of immune function and systemic inflammation, yet the effects of acute exercise intensity on immune activation, cytokine dynamics, and extracellular vesicle release in older adults remain incompletely characterized, particularly in a sex-specific context. This study investigated how a single session of acute continuous moderate versus intense exercise modulates immune cell subsets, cytokine levels, and EV profiles in healthy older individuals, with emphasis on sex-based differences.Thirty-three older adults completed either a moderate (n=14, 54-79 years; 60
KW  - cardiovascular fitness (Other)
KW  - extracellular vesicles (Other)
KW  - healthy aging (Other)
KW  - inflammaging (Other)
KW  - sex differences (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41208983
C2  - pmc:PMC12591881
DO  - DOI:10.3389/fimmu.2025.1661161
UR  - https://pub.dzne.de/record/281879
ER  -