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@ARTICLE{Haetzel:281910,
      author       = {Haetzel, Laura M. and Gründemann, Jan},
      title        = {{I}nhibitory inputs from thalamus promote resilient spiking
                      in tail of striatum},
      journal      = {iScience},
      volume       = {28},
      number       = {11},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-01252},
      pages        = {113880},
      year         = {2025},
      abstract     = {Thalamic afferents form glutamatergic synapses with
                      striatal medium spiny neurons (MSNs). These projections are
                      involved in complex learning processes and have primarily
                      been studied in rostral striatum. Caudal regions, such as
                      tail of striatum (TS), have only recently gained attention.
                      Medial geniculate body (auditory thalamus; MGB) provides
                      functional excitatory inputs to MSNs in TS; however, it is
                      unclear how MGB regulates striatal output signals. We
                      therefore performed optogenetics-assisted circuit mapping in
                      ex vivo brain slices to examine how MGB modulates neuronal
                      output in TS MSNs. Whole-cell recordings revealed that
                      activation of MGB terminals increases MSN firing
                      specifically at high levels of postsynaptic depolarization.
                      In addition to the well-described excitatory thalamostriatal
                      projections, we identified a sparse population of GABAergic
                      projection neurons in higher-order MGB that inhibit TS MSNs
                      through a GABAB-receptor-mediated mechanism. Together, these
                      results provide a conceptual framework for MGB-driven
                      state-dependent modulation of striatal output signals.},
      cin          = {AG Gründemann},
      ddc          = {050},
      cid          = {I:(DE-2719)5000069},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      experiment   = {EXP:(DE-2719)LMF-20190308},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.isci.2025.113880},
      url          = {https://pub.dzne.de/record/281910},
}