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| 001 | 281910 | ||
| 005 | 20251113095652.0 | ||
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| 100 | 1 | _ | |a Haetzel, Laura M. |0 P:(DE-2719)9002631 |b 0 |e First author |
| 245 | _ | _ | |a Inhibitory inputs from thalamus promote resilient spiking in tail of striatum |
| 260 | _ | _ | |a St. Louis |c 2025 |b Elsevier |
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| 520 | _ | _ | |a Thalamic afferents form glutamatergic synapses with striatal medium spiny neurons (MSNs). These projections are involved in complex learning processes and have primarily been studied in rostral striatum. Caudal regions, such as tail of striatum (TS), have only recently gained attention. Medial geniculate body (auditory thalamus; MGB) provides functional excitatory inputs to MSNs in TS; however, it is unclear how MGB regulates striatal output signals. We therefore performed optogenetics-assisted circuit mapping in ex vivo brain slices to examine how MGB modulates neuronal output in TS MSNs. Whole-cell recordings revealed that activation of MGB terminals increases MSN firing specifically at high levels of postsynaptic depolarization. In addition to the well-described excitatory thalamostriatal projections, we identified a sparse population of GABAergic projection neurons in higher-order MGB that inhibit TS MSNs through a GABAB-receptor-mediated mechanism. Together, these results provide a conceptual framework for MGB-driven state-dependent modulation of striatal output signals. |
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| 700 | 1 | _ | |a Gründemann, Jan |0 P:(DE-2719)9001219 |b 1 |e Last author |
| 773 | _ | _ | |a 10.1016/j.isci.2025.113880 |g Vol. 28, no. 11, p. 113880 - |0 PERI:(DE-600)2927064-9 |n 11 |p 113880 |t iScience |v 28 |y 2025 |x 2589-0042 |
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