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@ARTICLE{Favila:281911,
      author       = {Favila, Natalia and Capece Marsico, Jessica and Pacheco,
                      Catarina M. and Kenet, Selin and Escribano, Benjamin and
                      Bitterman, Yael and Gründemann, Jan and Lüthi, Andreas and
                      Krabbe, Sabine},
      title        = {{H}eterogeneous plasticity of amygdala interneurons in
                      associative learning and extinction},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-01253},
      pages        = {9926},
      year         = {2025},
      abstract     = {Neural circuits undergo experience-dependent plasticity to
                      form long-lasting memories, but how inhibitory interneurons
                      contribute to this process remains poorly understood. Using
                      miniature microscope calcium imaging, we monitored the
                      activity of large amygdala interneuron populations in freely
                      moving mice during fear learning and extinction. Here we
                      show that interneurons exhibit complex and heterogeneous
                      plasticity at both single-cell and ensemble levels across
                      memory acquisition, expression, and extinction. Analysis of
                      molecular interneuron subpopulations revealed that
                      disinhibitory vasoactive intestinal peptide (VIP)-expressing
                      cells are predominantly activated by salient external
                      stimuli, whereas the activity of projection neuron targeting
                      somatostatin (SST) interneurons additionally aligns with
                      internal behavioural states. Although responses within each
                      interneuron subtype are non-uniform, molecular identity
                      biases their functional role, producing weighted circuit
                      outputs that can flexibly regulate excitatory projection
                      neuron activity and plasticity. These findings demonstrate
                      that inhibitory interneurons actively shape the encoding and
                      stability of emotional memories, underscoring their
                      importance in adaptive learning.},
      cin          = {AG Krabbe / AG Gründemann},
      ddc          = {500},
      cid          = {I:(DE-2719)5000059 / I:(DE-2719)5000069},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1038/s41467-025-66122-y},
      url          = {https://pub.dzne.de/record/281911},
}