TY  - JOUR
AU  - Tanaka, Emi
AU  - Nihashi, Takashi
AU  - Kato, Takashi
AU  - Arahata, Yutaka
AU  - Takeda, Akinori
AU  - Sakurai, Keita
AU  - Yokoi, Katsunori
AU  - Iwata, Kaori
AU  - Diers, Kersten
AU  - Maess, Burkhard
AU  - Nakamura, Akinori
TI  - Modulation of middle-latency somatosensory evoked magnetic field waveforms associated with the pathophysiological states of Alzheimer's disease.
JO  - Journal of Alzheimer's disease
VL  - 108
IS  - 2
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2025-01259
SP  - 862 - 872
PY  - 2025
AB  - BackgroundAlzheimer's disease (AD) frequently causes epilepsy and myoclonus. These symptoms are thought to be associated with neuronal hyperexcitability, highlighting the need for biomarkers that reflect synaptic functional alterations.ObjectiveWe aimed to examine changes in neuronal excitability associated with AD progression using magnetoencephalography (MEG). Furthermore, we investigated the relationship between alterations in electromagnetic signals and other neuroimaging biomarkers.MethodsWe measured middle-latency somatosensory evoked magnetic fields (m-SEFs) following right median nerve stimulation in 45 individuals, comprising 6, 8, and 31 individuals with AD dementia (ADD), mild cognitive impairment (MCI), and cognitively healthy older adults, respectively. Cortical reactivity relative to the primary somatosensory response (N20 m) was assessed using normalized m-SEF waveforms. Additionally, we analyzed associations between these waveforms and amyloid-β (Aβ) deposition, regional glucose metabolism, and gray matter volume using positron-emission tomography and magnetic resonance imaging.ResultsThe m-SEF waveform exhibited six components (M2-M7) within 150 ms of the N20 m (M1) response. The m-SEF waveforms tended to be enlarged in ADD and MCI, with a significant enhancement of M2 in ADD. The amplitude of M7 at approximately 100 ms latency was significantly and positively correlated with local Aβ deposition in the sensorimotor cortex. Moreover, regional glucose hypometabolism in the hippocampus and pulvinar was significantly associated with enlargement of the M4, M6, and M7 components.ConclusionsThese findings indicate that cortical responses to somatosensory stimulation are modulated by AD progression. M-SEF may serve as a potential marker for evaluating cortical excitability in the sensorimotor cortex.
KW  - Humans
KW  - Alzheimer Disease: physiopathology
KW  - Alzheimer Disease: diagnostic imaging
KW  - Male
KW  - Evoked Potentials, Somatosensory: physiology
KW  - Aged
KW  - Female
KW  - Magnetoencephalography
KW  - Magnetic Resonance Imaging
KW  - Positron-Emission Tomography
KW  - Aged, 80 and over
KW  - Cognitive Dysfunction: physiopathology
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Median Nerve: physiopathology
KW  - Middle Aged
KW  - Amyloid beta-Peptides: metabolism
KW  - Somatosensory Cortex: physiopathology
KW  - Alzheimer's disease (Other)
KW  - amyloid-β protein (Other)
KW  - cortical excitability (Other)
KW  - evoked potentials (Other)
KW  - glucose metabolism (Other)
KW  - magnetoencephalography (Other)
KW  - somatosensory (Other)
KW  - Amyloid beta-Peptides (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41004660
DO  - DOI:10.1177/13872877251379466
UR  - https://pub.dzne.de/record/282288
ER  -