%0 Journal Article
%A Rodriguez-Vieitez, Elena
%A Rydell, Melissa T
%A Ullgren, Abbe
%A Montal, Victor
%A Illán-Gala, Ignacio
%A Fortea, Juan
%A Jelic, Vesna
%A Bouzigues, Arabella
%A Russell, Lucy L
%A Foster, Phoebe H
%A Ferry-Bolder, Eve
%A van Swieten, John C
%A Jiskoot, Lize C
%A Seelaar, Harro
%A Sanchez-Valle, Raquel
%A Laforce, Robert
%A Galimberti, Daniela
%A Vandenberghe, Rik
%A de Mendonça, Alexandre
%A Tiraboschi, Pietro
%A Santana, Isabel
%A Gerhard, Alexander
%A Levin, Johannes
%A Sorbi, Sandro
%A Otto, Markus
%A Pasquier, Florence
%A Ducharme, Simon
%A Butler, Chris R
%A Le Ber, Isabelle
%A Finger, Elizabeth
%A Tartaglia, Maria Carmela
%A Masellis, Mario
%A Rowe, James B
%A Synofzik, Matthis
%A Moreno, Fermin
%A Borroni, Barbara
%A Rohrer, Jonathan D
%A Westman, Eric
%A Graff, Caroline
%T Cortical microstructure is associated with disease severity and clinical progression in genetic frontotemporal dementia: a GENFI study.
%J Molecular psychiatry
%V 30
%N 12
%@ 1359-4184
%C [London]
%I Springer Nature
%M DZNE-2025-01260
%P 5800 - 5812
%D 2025
%X The study of genetic frontotemporal dementia (FTD) allows investigating its earliest presymptomatic stages. Using cross-sectional T1-weighted and diffusion-weighted MRI, we test the hypothesis that cortical microstructural alterations, quantified as cortical mean diffusivity (cMD), are detectable earlier and are more strongly associated with clinical progression than cortical thickness (CTh). The sample comprised n = 710 individuals (47.8 ± 13.5 years, 56.6
%K Humans
%K Female
%K Male
%K Frontotemporal Dementia: genetics
%K Frontotemporal Dementia: pathology
%K Frontotemporal Dementia: diagnostic imaging
%K Middle Aged
%K Disease Progression
%K tau Proteins: genetics
%K C9orf72 Protein: genetics
%K Progranulins: genetics
%K Adult
%K Cerebral Cortex: pathology
%K Cerebral Cortex: diagnostic imaging
%K Cross-Sectional Studies
%K Aged
%K Mutation: genetics
%K Magnetic Resonance Imaging: methods
%K Severity of Illness Index
%K Diffusion Magnetic Resonance Imaging: methods
%K tau Proteins (NLM Chemicals)
%K C9orf72 Protein (NLM Chemicals)
%K Progranulins (NLM Chemicals)
%K MAPT protein, human (NLM Chemicals)
%K GRN protein, human (NLM Chemicals)
%K C9orf72 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41068257
%2 pmc:PMC12602311
%R 10.1038/s41380-025-03280-x
%U https://pub.dzne.de/record/282289