TY  - JOUR
AU  - Rodriguez-Vieitez, Elena
AU  - Rydell, Melissa T
AU  - Ullgren, Abbe
AU  - Montal, Victor
AU  - Illán-Gala, Ignacio
AU  - Fortea, Juan
AU  - Jelic, Vesna
AU  - Bouzigues, Arabella
AU  - Russell, Lucy L
AU  - Foster, Phoebe H
AU  - Ferry-Bolder, Eve
AU  - van Swieten, John C
AU  - Jiskoot, Lize C
AU  - Seelaar, Harro
AU  - Sanchez-Valle, Raquel
AU  - Laforce, Robert
AU  - Galimberti, Daniela
AU  - Vandenberghe, Rik
AU  - de Mendonça, Alexandre
AU  - Tiraboschi, Pietro
AU  - Santana, Isabel
AU  - Gerhard, Alexander
AU  - Levin, Johannes
AU  - Sorbi, Sandro
AU  - Otto, Markus
AU  - Pasquier, Florence
AU  - Ducharme, Simon
AU  - Butler, Chris R
AU  - Le Ber, Isabelle
AU  - Finger, Elizabeth
AU  - Tartaglia, Maria Carmela
AU  - Masellis, Mario
AU  - Rowe, James B
AU  - Synofzik, Matthis
AU  - Moreno, Fermin
AU  - Borroni, Barbara
AU  - Rohrer, Jonathan D
AU  - Westman, Eric
AU  - Graff, Caroline
TI  - Cortical microstructure is associated with disease severity and clinical progression in genetic frontotemporal dementia: a GENFI study.
JO  - Molecular psychiatry
VL  - 30
IS  - 12
SN  - 1359-4184
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-01260
SP  - 5800 - 5812
PY  - 2025
AB  - The study of genetic frontotemporal dementia (FTD) allows investigating its earliest presymptomatic stages. Using cross-sectional T1-weighted and diffusion-weighted MRI, we test the hypothesis that cortical microstructural alterations, quantified as cortical mean diffusivity (cMD), are detectable earlier and are more strongly associated with clinical progression than cortical thickness (CTh). The sample comprised n = 710 individuals (47.8 ± 13.5 years, 56.6
KW  - Humans
KW  - Female
KW  - Male
KW  - Frontotemporal Dementia: genetics
KW  - Frontotemporal Dementia: pathology
KW  - Frontotemporal Dementia: diagnostic imaging
KW  - Middle Aged
KW  - Disease Progression
KW  - tau Proteins: genetics
KW  - C9orf72 Protein: genetics
KW  - Progranulins: genetics
KW  - Adult
KW  - Cerebral Cortex: pathology
KW  - Cerebral Cortex: diagnostic imaging
KW  - Cross-Sectional Studies
KW  - Aged
KW  - Mutation: genetics
KW  - Magnetic Resonance Imaging: methods
KW  - Severity of Illness Index
KW  - Diffusion Magnetic Resonance Imaging: methods
KW  - tau Proteins (NLM Chemicals)
KW  - C9orf72 Protein (NLM Chemicals)
KW  - Progranulins (NLM Chemicals)
KW  - MAPT protein, human (NLM Chemicals)
KW  - GRN protein, human (NLM Chemicals)
KW  - C9orf72 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41068257
C2  - pmc:PMC12602311
DO  - DOI:10.1038/s41380-025-03280-x
UR  - https://pub.dzne.de/record/282289
ER  -