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000282294 1001_ $$aMimoso, Tiago$$b0
000282294 245__ $$aBrain-derived synaptic vesicles have an intrinsic ability to sequester tubulin.
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000282294 520__ $$aThe presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the synaptic vesicle cluster to the local dynamics of microtubule ends. Nonetheless, one question remains open, namely whether the vesicles influence the availability of tubulin within the synaptic compartment.An analysis of previously published live imaging experiments indicates that tubulin is strongly enriched in the synaptic vesicle cluster. To analyze the vesicle-tubulin interaction directly, we isolated vesicles from the mouse brain and imaged them together with fluorescent tubulin in vitro. We found that soluble tubulin is collected by synaptic vesicles in physiological buffers, resulting in the formation of tubulin-rich regions (TRRs) on the respective vesicle clusters.We conclude that the synaptic vesicle cluster is indeed able to recruit soluble tubulin.
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000282294 650_7 $$2Other$$aCytoskeleton
000282294 650_7 $$2Other$$aMicrotubules
000282294 650_7 $$2Other$$aSynapse
000282294 650_7 $$2Other$$aSynaptic vesicle cluster
000282294 650_7 $$2Other$$aSynaptic vesicles
000282294 650_7 $$2Other$$aTubulin
000282294 650_7 $$2NLM Chemicals$$aTubulin
000282294 650_2 $$2MeSH$$aAnimals
000282294 650_2 $$2MeSH$$aTubulin: metabolism
000282294 650_2 $$2MeSH$$aSynaptic Vesicles: metabolism
000282294 650_2 $$2MeSH$$aMice
000282294 650_2 $$2MeSH$$aBrain: metabolism
000282294 650_2 $$2MeSH$$aMicrotubules: metabolism
000282294 7001_ $$0P:(DE-2719)9002676$$aKorobeinikov, Aleksandr$$b1$$udzne
000282294 7001_ $$aStein, Alexander$$b2
000282294 7001_ $$0P:(DE-2719)9000670$$aMilovanovic, Dragomir$$b3$$udzne
000282294 7001_ $$aRizzoli, Silvio O$$b4
000282294 7001_ $$aKöster, Sarah$$b5
000282294 7001_ $$aReshetniak, Sofiia$$b6
000282294 773__ $$0PERI:(DE-600)2133020-7$$a10.1186/s12915-025-02464-9$$gVol. 23, no. 1, p. 340$$n1$$p340$$tBMC biology$$v23$$x1741-7007$$y2025
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