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@ARTICLE{Mimoso:282294,
      author       = {Mimoso, Tiago and Korobeinikov, Aleksandr and Stein,
                      Alexander and Milovanovic, Dragomir and Rizzoli, Silvio O
                      and Köster, Sarah and Reshetniak, Sofiia},
      title        = {{B}rain-derived synaptic vesicles have an intrinsic ability
                      to sequester tubulin.},
      journal      = {BMC biology},
      volume       = {23},
      number       = {1},
      issn         = {1741-7007},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2025-01264},
      pages        = {340},
      year         = {2025},
      abstract     = {The presence and function of microtubules within the
                      synaptic bouton has long been under investigation. In recent
                      years, evidence has accumulated that connects the synaptic
                      vesicle cluster to the local dynamics of microtubule ends.
                      Nonetheless, one question remains open, namely whether the
                      vesicles influence the availability of tubulin within the
                      synaptic compartment.An analysis of previously published
                      live imaging experiments indicates that tubulin is strongly
                      enriched in the synaptic vesicle cluster. To analyze the
                      vesicle-tubulin interaction directly, we isolated vesicles
                      from the mouse brain and imaged them together with
                      fluorescent tubulin in vitro. We found that soluble tubulin
                      is collected by synaptic vesicles in physiological buffers,
                      resulting in the formation of tubulin-rich regions (TRRs) on
                      the respective vesicle clusters.We conclude that the
                      synaptic vesicle cluster is indeed able to recruit soluble
                      tubulin.},
      keywords     = {Animals / Tubulin: metabolism / Synaptic Vesicles:
                      metabolism / Mice / Brain: metabolism / Microtubules:
                      metabolism / Cytoskeleton (Other) / Microtubules (Other) /
                      Synapse (Other) / Synaptic vesicle cluster (Other) /
                      Synaptic vesicles (Other) / Tubulin (Other) / Tubulin (NLM
                      Chemicals)},
      cin          = {AG Milovanovic (Berlin) / AG Milovanovic (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1813002 / I:(DE-2719)1013043},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41239319},
      pmc          = {pmc:PMC12619239},
      doi          = {10.1186/s12915-025-02464-9},
      url          = {https://pub.dzne.de/record/282294},
}