%0 Journal Article
%A Wilkens, Ida
%A Bebermeier, Sarah
%A Heine, Johanne
%A Ruf, Viktoria Constanze
%A Compta, Yaroslau
%A Molina Porcel, Laura
%A Troakes, Claire
%A Vamanu, Albert
%A Downes, Sophia
%A Irwin, David John
%A Cohen, Jesse
%A Lee, Edward B
%A Nilsson, Christer F
%A Englund, Elisabet M
%A Nemati, Mojtaba
%A Katzdobler, Sabrina
%A Levin, Johannes
%A Bernhardt, Alexander Maximilian
%A Pantelyat, Alexander
%A Seemiller, Joseph
%A Berger, Stephen
%A Van Swieten, John C
%A Dopper, Elise G P
%A Rozemuller, Annemieke J M
%A Kovacs, Gabor G
%A Bendahan, Nathaniel
%A Lang, Anthony E
%A Herms, Jochen
%A Höglinger, Günter U
%A Hopfner, Franziska
%T Multiple System Atrophy Without Dysautonomia: An Autopsy-Confirmed Study.
%J Neurology
%V 105
%N 11
%@ 0028-3878
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DZNE-2025-01268
%P e214316
%D 2025
%X Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia. Recent Movement Disorder Society (MDS) criteria allow for the clinical diagnosis of MSA based solely on motor symptoms, without requiring dysautonomia. This study aimed to evaluate the frequency and disease trajectory of MSA patients without dysautonomia compared with those with autonomic involvement.A multicenter cohort of autopsy-confirmed patients with MSA was analyzed for demographic characteristics, symptom onset, and progression of parkinsonism, cerebellar syndrome, and dysautonomia. Clinical data were collected through standardized chart reviews across participating centers and categorized using the MDS-MSA criteria. Patients were grouped according to their initial symptom complex and tracked for the evolution of additional symptoms. Analyses included time to development of further symptom complexes, age at symptom onset, disease duration, and phenotype at the last recorded visit. Patients with motor symptoms only were matched to patients with similar demographics but with dysautonomia. Statistical methods included ANOVA, t tests, Welch t tests, and χ2 tests, with significance set at p < 0.05.Among 140 patients (mean age at onset 62.3 ± 8.9 years; 44
%K Humans
%K Multiple System Atrophy: pathology
%K Multiple System Atrophy: diagnosis
%K Multiple System Atrophy: physiopathology
%K Female
%K Male
%K Middle Aged
%K Aged
%K Autopsy
%K Primary Dysautonomias
%K Disease Progression
%K Cohort Studies
%K Parkinsonian Disorders
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41232058
%2 pmc:PMC12615010
%R 10.1212/WNL.0000000000214316
%U https://pub.dzne.de/record/282298