TY  - JOUR
AU  - Weinreich, Marcel
AU  - McDonough, Harry
AU  - Heverin, Mark
AU  - Domhnaill, Éanna Mac
AU  - Yacovzada, Nancy
AU  - Magen, Iddo
AU  - Cohen, Yahel
AU  - Harvey, Calum
AU  - Elazzab, Ahmed
AU  - Gornall, Sarah
AU  - Boddy, Sarah
AU  - Alix, James J P
AU  - Kurz, Julian M
AU  - Kenna, Kevin P
AU  - Zhang, Sai
AU  - Iacoangeli, Alfredo
AU  - Al-Khleifat, Ahmad
AU  - Snyder, Michael P
AU  - Hobson, Esther
AU  - Chio, Adriano
AU  - Malaspina, Andrea
AU  - Hermann, Andreas
AU  - Ingre, Caroline
AU  - Costa, Juan Vazquez
AU  - van den Berg, Leonard
AU  - Panadés, Monica Povedano
AU  - van Damme, Philip
AU  - Corcia, Phillipe
AU  - de Carvalho, Mamede
AU  - Al-Chalabi, Ammar
AU  - Hornstein, Eran
AU  - Elhaik, Eran
AU  - Shaw, Pamela J
AU  - Hardiman, Orla
AU  - McDermott, Christopher
AU  - Cooper-Knock, Johnathan
TI  - Optimised machine learning for time-to-event prediction in healthcare applied to timing of gastrostomy in ALS: a multi-centre, retrospective model development and validation study.
JO  - EBioMedicine
VL  - 121
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2025-01271
SP  - 105962
PY  - 2025
AB  - Amyotrophic lateral sclerosis (ALS) is invariably fatal but there are large variations in the rate of progression. The lack of predictability can make it difficult to plan clinical interventions. This includes the requirement for gastrostomy where early or late placement can adversely impact quality of life and survival.We designed a model to predict the timing of gastrostomy requirement in ALS as indicated by 5
KW  - Humans
KW  - Gastrostomy: methods
KW  - Amyotrophic Lateral Sclerosis: diagnosis
KW  - Amyotrophic Lateral Sclerosis: surgery
KW  - Amyotrophic Lateral Sclerosis: therapy
KW  - Machine Learning
KW  - Male
KW  - Female
KW  - Retrospective Studies
KW  - Middle Aged
KW  - Aged
KW  - Europe
KW  - Bayes Theorem
KW  - Amyotrophic lateral sclerosis (ALS) (Other)
KW  - Gastrostomy (Other)
KW  - Machine learning (Other)
KW  - Personalised medicine (Other)
KW  - Time-to-event prediction (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41075354
C2  - pmc:PMC12547709
DO  - DOI:10.1016/j.ebiom.2025.105962
UR  - https://pub.dzne.de/record/282301
ER  -