TY  - EJOUR
AU  - Mantey, Richard
AU  - Hu, Jialu
AU  - Touhidinia, Maryam
AU  - Butt, Tanzeem
AU  - Sidky, Ahmed Mokhtar
AU  - Sobhani, Roohollah
AU  - Estrada, Santiago
AU  - Haendler, Kristian
AU  - De Domenico, Elena
AU  - Beyer, Marc D.
AU  - Breteler, Monique M. B.
AU  - Aziz, N. Ahmad
TI  - Tandem Repeat Polymorphisms Are Associated with Brain Structure: Results of Two Large Population-based Studies
M1  - DZNE-2025-01290
PY  - 2025
AB  - Although genome-wide association studies (GWAS) have uncovered many genetic variants linked to brain structure, much of its heritability remains unexplained. Short tandem repeats (STRs), which are rarely considered in GWAS, may contribute to this “missing heritability”. Using targeted deep sequencing, we systematically assessed the relationship between ∼3000 polymorphic STRs and brain imaging-derived phenotypes across 2958 participants of the Rhineland Study. Expansion of an intronic CA repeat in PRR14L was associated with larger thalamic volume (standardized β [95
LB  - PUB:(DE-HGF)25
DO  - DOI:10.1101/2025.11.14.25340228
UR  - https://pub.dzne.de/record/282329
ER  -