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000282333 1001_ $$0P:(DE-2719)2814138$$aOuteiro, Tiago Fleming$$b0$$eFirst author
000282333 245__ $$aProtein misfolding: understanding biology to classify and treat synucleinopathies.
000282333 260__ $$aWien [u.a.]$$bSpringer$$c2025
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000282333 520__ $$aProtein misfolding and aggregation is a major pathological hallmark in a variety of human conditions, including cancer, diabetes, and neurodegeneration. However, we still do not fully understand the role of protein accumulation in disease. Interestingly, recent breakthroughs in artificial intelligence (AI) are having a tremendous impact on our ability to predict three-dimensional protein structures and understand the molecular rules governing protein folding/misfolding. This progress will enable us to understand how intrinsic and extrinsic factors trigger protein misfolding, thereby changing protein function. These changes, in some cases, are related to normal biological responses and, in other cases, associated with pathological alterations, such as those found in many neurodegenerative disorders. Here, we provide a brief historical perspective of how findings in the field of prion diseases and prion biology have enabled tremendous advances that are now forming the basis for our understanding of disease processes and discuss how this knowledge is now emerging as central for our ability to classify, diagnose, and treat devastating neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.
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000282333 650_7 $$2Other$$aAlpha-synuclein
000282333 650_7 $$2Other$$aBiomarkers
000282333 650_7 $$2Other$$aDisease classification
000282333 650_7 $$2Other$$aNeurodegeneration
000282333 650_7 $$2Other$$aParkinson’s disease
000282333 650_7 $$2Other$$aProtein aggregation
000282333 650_2 $$2MeSH$$aHumans
000282333 650_2 $$2MeSH$$aSynucleinopathies: metabolism
000282333 650_2 $$2MeSH$$aSynucleinopathies: classification
000282333 650_2 $$2MeSH$$aSynucleinopathies: therapy
000282333 650_2 $$2MeSH$$aProtein Folding
000282333 650_2 $$2MeSH$$aProteostasis Deficiencies: metabolism
000282333 650_2 $$2MeSH$$aProteostasis Deficiencies: therapy
000282333 650_2 $$2MeSH$$aAnimals
000282333 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter$$b1$$udzne
000282333 7001_ $$aLang, Anthony E$$b2
000282333 7001_ $$aVieira, Tuane C R G$$b3
000282333 773__ $$0PERI:(DE-600)1481655-6$$a10.1007/s00702-025-02889-0$$gVol. 132, no. 11, p. 1645 - 1654$$n11$$p1645 - 1654$$tJournal of neural transmission$$v132$$x0375-9245$$y2025
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