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000282475 1001_ $$aMurray, Melissa E$$b0
000282475 245__ $$aAccelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration.
000282475 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2025
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000282475 520__ $$aTransformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies. These approaches, spanning multi-omics studies and machine learning applications, will drive discovery for the identification of biomarkers, therapeutic targets, and complex disease patterns through comprehensive analyses of postmortem human brain tissue. Yet critical challenges remain, including the sustainability of brain banks, expanding donor participation, strengthening training pipelines, enabling rapid autopsies, supporting collaborative platforms, and integrating data across modalities. Innovations in digital pathology, tissue quality enhancement, harmonization of data standards, and machine learning integration offer opportunities to accelerate tissue-level 'pathomics' research in brain health through cross-disciplinary collaborations. Lessons from neuroimaging, particularly in establishing common data frameworks and multi-site collaborations, offer a valuable roadmap for streamlining innovations. In this perspective, we outline actionable solutions for leveraging existing resources and strengthening collaboration -where we envision future opportunities to drive translational discoveries stemming from transformative neuropathology.
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000282475 650_7 $$2Other$$abiomarkers
000282475 650_7 $$2Other$$adigital pathology
000282475 650_7 $$2Other$$amachine learning
000282475 650_7 $$2Other$$aneuropathology
000282475 650_7 $$2Other$$apathomics
000282475 650_7 $$2Other$$aspatial biology
000282475 650_2 $$2MeSH$$aHumans
000282475 650_2 $$2MeSH$$aBrain: pathology
000282475 650_2 $$2MeSH$$aBrain: diagnostic imaging
000282475 650_2 $$2MeSH$$aAging: pathology
000282475 650_2 $$2MeSH$$aNeurodegenerative Diseases: pathology
000282475 650_2 $$2MeSH$$aNeuropathology: methods
000282475 650_2 $$2MeSH$$aNeuropathology: trends
000282475 650_2 $$2MeSH$$aNeuroimaging: methods
000282475 650_2 $$2MeSH$$aBiomedical Research
000282475 7001_ $$aSmith, Colin$$b1
000282475 7001_ $$aMenon, Vilas$$b2
000282475 7001_ $$aKeene, C Dirk$$b3
000282475 7001_ $$aLein, Ed$$b4
000282475 7001_ $$aHawrylycz, Michael$$b5
000282475 7001_ $$aAguzzi, Adriano$$b6
000282475 7001_ $$aBenedetti, Brett$$b7
000282475 7001_ $$aBrose, Katja$$b8
000282475 7001_ $$aCaetano-Anolles, Kelsey$$b9
000282475 7001_ $$aSillero, Maria Inmaculada Cobos$$b10
000282475 7001_ $$aCrary, John F$$b11
000282475 7001_ $$aDe Jager, Philip L$$b12
000282475 7001_ $$aFaustin, Arline$$b13
000282475 7001_ $$aFlanagan, Margaret E$$b14
000282475 7001_ $$0P:(DE-2719)9002754$$aGokce, Ozgun$$b15$$udzne
000282475 7001_ $$aGrant, Seth G N$$b16
000282475 7001_ $$aGrinberg, Lea T$$b17
000282475 7001_ $$aGutman, David A$$b18
000282475 7001_ $$aHillman, Elizabeth M C$$b19
000282475 7001_ $$aHuang, Zhi$$b20
000282475 7001_ $$aIrwin, David J$$b21
000282475 7001_ $$aJones, David T$$b22
000282475 7001_ $$aKapasi, Alifiya$$b23
000282475 7001_ $$aKarch, Celeste M$$b24
000282475 7001_ $$aKukull, Walter T$$b25
000282475 7001_ $$aLashley, Tammaryn$$b26
000282475 7001_ $$aLee, Edward B$$b27
000282475 7001_ $$aLehner, Thomas$$b28
000282475 7001_ $$aParkkinen, Laura$$b29
000282475 7001_ $$aPedersen, Maria$$b30
000282475 7001_ $$aPritchett, Dominique$$b31
000282475 7001_ $$aRutledge, Matthew H$$b32
000282475 7001_ $$aSchneider, Julie A$$b33
000282475 7001_ $$aSeeley, William W$$b34
000282475 7001_ $$aShepherd, Claire E$$b35
000282475 7001_ $$aSpires-Jones, Tara L$$b36
000282475 7001_ $$aSteen, Judith A$$b37
000282475 7001_ $$aSutherland, Margaret$$b38
000282475 7001_ $$aVickovic, Sanja$$b39
000282475 7001_ $$aZhang, Bin$$b40
000282475 7001_ $$aStewart, David J$$b41
000282475 7001_ $$aKeiser, Michael J$$b42
000282475 7001_ $$aVogel, Jacob W$$b43
000282475 7001_ $$aDugger, Brittany N$$b44
000282475 7001_ $$aPhatnani, Hemali$$b45
000282475 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2025.06.014$$gVol. 113, no. 22, p. 3703 - 3721$$n22$$p3703 - 3721$$tNeuron$$v113$$x0896-6273$$y2025
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