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@ARTICLE{Murray:282475,
      author       = {Murray, Melissa E and Smith, Colin and Menon, Vilas and
                      Keene, C Dirk and Lein, Ed and Hawrylycz, Michael and
                      Aguzzi, Adriano and Benedetti, Brett and Brose, Katja and
                      Caetano-Anolles, Kelsey and Sillero, Maria Inmaculada Cobos
                      and Crary, John F and De Jager, Philip L and Faustin, Arline
                      and Flanagan, Margaret E and Gokce, Ozgun and Grant, Seth G
                      N and Grinberg, Lea T and Gutman, David A and Hillman,
                      Elizabeth M C and Huang, Zhi and Irwin, David J and Jones,
                      David T and Kapasi, Alifiya and Karch, Celeste M and Kukull,
                      Walter T and Lashley, Tammaryn and Lee, Edward B and Lehner,
                      Thomas and Parkkinen, Laura and Pedersen, Maria and
                      Pritchett, Dominique and Rutledge, Matthew H and Schneider,
                      Julie A and Seeley, William W and Shepherd, Claire E and
                      Spires-Jones, Tara L and Steen, Judith A and Sutherland,
                      Margaret and Vickovic, Sanja and Zhang, Bin and Stewart,
                      David J and Keiser, Michael J and Vogel, Jacob W and Dugger,
                      Brittany N and Phatnani, Hemali},
      title        = {{A}ccelerating biomedical discoveries in brain health
                      through transformative neuropathology of aging and
                      neurodegeneration.},
      journal      = {Neuron},
      volume       = {113},
      number       = {22},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DZNE-2025-01298},
      pages        = {3703 - 3721},
      year         = {2025},
      abstract     = {Transformative neuropathology is redefining human brain
                      research by integrating foundational descriptive pathology
                      with advanced methodologies. These approaches, spanning
                      multi-omics studies and machine learning applications, will
                      drive discovery for the identification of biomarkers,
                      therapeutic targets, and complex disease patterns through
                      comprehensive analyses of postmortem human brain tissue. Yet
                      critical challenges remain, including the sustainability of
                      brain banks, expanding donor participation, strengthening
                      training pipelines, enabling rapid autopsies, supporting
                      collaborative platforms, and integrating data across
                      modalities. Innovations in digital pathology, tissue quality
                      enhancement, harmonization of data standards, and machine
                      learning integration offer opportunities to accelerate
                      tissue-level 'pathomics' research in brain health through
                      cross-disciplinary collaborations. Lessons from
                      neuroimaging, particularly in establishing common data
                      frameworks and multi-site collaborations, offer a valuable
                      roadmap for streamlining innovations. In this perspective,
                      we outline actionable solutions for leveraging existing
                      resources and strengthening collaboration -where we envision
                      future opportunities to drive translational discoveries
                      stemming from transformative neuropathology.},
      subtyp        = {Review Article},
      keywords     = {Humans / Brain: pathology / Brain: diagnostic imaging /
                      Aging: pathology / Neurodegenerative Diseases: pathology /
                      Neuropathology: methods / Neuropathology: trends /
                      Neuroimaging: methods / Biomedical Research / biomarkers
                      (Other) / digital pathology (Other) / machine learning
                      (Other) / neuropathology (Other) / pathomics (Other) /
                      spatial biology (Other)},
      cin          = {AG Gokce},
      ddc          = {610},
      cid          = {I:(DE-2719)1013041},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40683248},
      pmc          = {pmc:PMC12313173},
      doi          = {10.1016/j.neuron.2025.06.014},
      url          = {https://pub.dzne.de/record/282475},
}