%0 Journal Article
%A Yan, Shijun
%A Sahoo, Anis
%A Zerenner, Tanja
%A Marek, Kenneth
%A Sommerauer, Michael
%A Oertel, Wolfgang
%A Hu, Michele T.
%A Tofaris, George K.
%T Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder
%J Annals of neurology
%V AOP
%@ 0364-5134
%C Hoboken, NJ
%I Wiley-Blackwell
%M DZNE-2025-01302
%P ana.78109
%D 2025
%X ObjectiveAssess the performance of serum phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD.MethodsWe measured serum p-tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300), including individuals who phenoconverted to Parkinson's disease (PD) (n = 51), dementia with Lewy bodies (DLB) (n = 22), and multiple system atrophy (MSA) (n = 5).ResultsSerum p-tau217 levels were increased in individuals with iRBD and cognitive impairment (CI) on testing defined as Montreal Cognitive Assessment <26 or subthreshold parkinsonism. p-Tau217 differentiated individuals with iRBD who developed PD with CI (PD-CI) or DLB from PD phenoconverters with normal cognition (area under curve [AUC] = 0.82; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1002/ana.78109
%U https://pub.dzne.de/record/282539