TY  - JOUR
AU  - Yan, Shijun
AU  - Sahoo, Anis
AU  - Zerenner, Tanja
AU  - Marek, Kenneth
AU  - Sommerauer, Michael
AU  - Oertel, Wolfgang
AU  - Hu, Michele T.
AU  - Tofaris, George K.
TI  - Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder
JO  - Annals of neurology
VL  - AOP
SN  - 0364-5134
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DZNE-2025-01302
SP  - ana.78109
PY  - 2025
AB  - ObjectiveAssess the performance of serum phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD.MethodsWe measured serum p-tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300), including individuals who phenoconverted to Parkinson's disease (PD) (n = 51), dementia with Lewy bodies (DLB) (n = 22), and multiple system atrophy (MSA) (n = 5).ResultsSerum p-tau217 levels were increased in individuals with iRBD and cognitive impairment (CI) on testing defined as Montreal Cognitive Assessment <26 or subthreshold parkinsonism. p-Tau217 differentiated individuals with iRBD who developed PD with CI (PD-CI) or DLB from PD phenoconverters with normal cognition (area under curve [AUC] = 0.82; 95
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1002/ana.78109
UR  - https://pub.dzne.de/record/282539
ER  -