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000282541 1001_ $$0P:(DE-2719)9001870$$aBlotenberg, Iris$$b0$$eFirst author
000282541 245__ $$aToward targeted dementia prevention: Population attributable fractions and risk profiles in Germany
000282541 260__ $$aHoboken, NJ$$bWiley$$c2025
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000282541 520__ $$aINTRODUCTIONEffective dementia prevention requires understanding the distribution of modifiable risk factors and identifying high-risk subgroups. We estimated the prevention potential in Germany and identified risk profiles to inform precision public health.METHODSWe analyzed nationally representative data from the 2023 German Aging Survey (n = 4992). Population attributable fractions and potential impact fractions were computed for established modifiable risk factors. Relative risks were taken from meta-analyses. Latent class analysis identified risk profiles.RESULTSAn estimated 36% of dementia cases in Germany are attributable to modifiable risk factors. Reducing their prevalence by 15%–30% could prevent 170,000–330,000 cases by 2050. We identified four risk profiles—metabolic, sensory impairment, alcohol, and lower-risk—each associated with demographic and regional characteristics.DISCUSSIONOur findings highlight considerable national prevention potential and reveal population subgroups with shared risk patterns. These profiles provide a foundation for designing targeted, equitable, and efficient dementia prevention strategies.Highlights36% of dementia cases in Germany are linked to modifiable risk factors.A 15% reduction in risk factor prevalence could prevent 170,000 cases by 2050.Key contributors: depression, hearing loss, low education, and obesity.Data-driven risk profiles identified (e.g., metabolic, sensory, low-risk).Risk profiles strongly associated with sociodemographic characteristics.
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000282541 7001_ $$0P:(DE-2719)2290613$$aThyrian, Jochen René$$b1$$eLast author$$udzne
000282541 773__ $$0PERI:(DE-600)2832898-X$$a10.1002/dad2.70225$$gVol. 17, no. 4, p. e70225$$n4$$pe70225$$tAlzheimer's & dementia / Diagnosis, assessment & disease monitoring$$v17$$x2352-8729$$y2025
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