TY  - JOUR
AU  - Lepenies, Laura K.
AU  - Seidling, Hanna M.
AU  - Pabst, Alexander
AU  - Luppa, Melanie
AU  - Döhring, Juliane
AU  - Williamson, Martin
AU  - Frese, Thomas
AU  - Gensichen, Jochen
AU  - Hoffmann, Wolfgang
AU  - Kaduszkiewicz, Hanna
AU  - König, Hans-Helmut
AU  - Thyrian, Jochen René
AU  - Wiese, Birgitt
AU  - Riedel-Heller, Steffi G.
AU  - Czock, David
TI  - Deprescribing drugs with anticholinergic effects in older patients with increased risk of dementia in the multicomponent intervention study AgeWell.de
JO  - British journal of clinical pharmacology
VL  - 91
IS  - 12
SN  - 0306-5251
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DZNE-2025-01305
SP  - 3489 - 3500
PY  - 2025
AB  - AimDrugs with anticholinergic effects are often considered as potentially inappropriate medications, especially for older patients, and deprescribing such drugs may improve cognitive function. The aim was to investigate the effectiveness of counselling on drug risks as part of a multimodal intervention to prevent cognitive decline.MethodsThe AgeWell.de study, a multi-centre, cluster-randomized controlled study, was conducted in 123 German general practices between June 2018 and January 2022. The study included a multicomponent intervention programme for patients at increased risk of dementia, delivered over a 2-year period. As part of the medication optimisation intervention, patient data and medication records were screened to identify medication risks and provide recommendations to general practitioners.ResultsIn total, 808 patients with complete data were included in the present analysis (intervention group = 374, control group = 434). At baseline, 132 (16.8
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1002/bcp.70194
UR  - https://pub.dzne.de/record/282542
ER  -