000282546 001__ 282546
000282546 005__ 20251218103441.0
000282546 0247_ $$2doi$$a10.1016/j.sleep.2025.108663
000282546 0247_ $$2pmid$$apmid:41232306
000282546 0247_ $$2ISSN$$a1389-9457
000282546 0247_ $$2ISSN$$a1878-5506
000282546 037__ $$aDZNE-2025-01309
000282546 041__ $$aEnglish
000282546 082__ $$a610
000282546 1001_ $$0P:(DE-2719)9002802$$aEinspänner, Eric$$b0$$udzne
000282546 245__ $$aA multimodal 7T MRI and biomarker study reveals reversible brain changes following acute sleep deprivation.
000282546 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2025
000282546 3367_ $$2DRIVER$$aarticle
000282546 3367_ $$2DataCite$$aOutput Types/Journal article
000282546 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1764670069_28228
000282546 3367_ $$2BibTeX$$aARTICLE
000282546 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000282546 3367_ $$00$$2EndNote$$aJournal Article
000282546 520__ $$aAcute sleep deprivation is known to impair vigilance performance and alter brain physiology. This study investigates structural, physiological and cognitive effects of one night of sleep deprivation (SD) and subsequent recovery. Thirty healthy participants underwent (18M/12F, mean age 28.0 ± 4.7 years, range 20-38) a multimodal assessment including 7T MRI, plasma biomarker analysis, and Psychomotor Vigilance Task (PVT) testing at three time points: baseline, after 24 h of SD, and following a 72-h recovery period. Our results demonstrate that SD induced a significant increase in total perivascular space (PVS) volume (from 6711.5 mm3 to 7475.3 mm3; p < 0.001), a marker of impaired glymphatic function, which completely normalized after recovery. These macrostructural changes were accompanied by reversible microstructural alterations, including decreased T1 relaxation times and shifts in quantitative susceptibility mapping (QSM) in multiple brain regions, indicative of dynamic fluid shifts. Systemically, SD led to an increase in pro-inflammatory markers, notably MMP-9 (from 52.3 pg/mL to 69.2 pg/mL; p < 0.05), and changes in multiple peripheral biomarkers. Behaviorally, participants exhibited significantly more attentional lapses (slowest 10 % RT: 386.4 ms-410 ms; p < 0.05), which were also reversed upon recovery. In conclusion, a single night of SD triggers a cascade of interconnected and fully reversible physiological changes, likely initiated by transient glymphatic disruption. Healthy individuals are able to recover mostly from one night of SD, suggesting that adverse effects of SD, when not in a chronic state, can potentially be reversed.
000282546 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000282546 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000282546 650_7 $$2Other$$a7T MRI
000282546 650_7 $$2Other$$aBiomarkers
000282546 650_7 $$2Other$$aNeuroimaging
000282546 650_7 $$2Other$$aPVS
000282546 650_7 $$2Other$$aSleep deprivation
000282546 7001_ $$0P:(DE-2719)9002178$$aMattern, Hendrik$$b1$$udzne
000282546 7001_ $$aGrossmann, Heiko$$b2
000282546 7001_ $$aKhadhraoui, Eya$$b3
000282546 7001_ $$aMüller, Sebastian J$$b4
000282546 7001_ $$aGarza, Alejandra P$$b5
000282546 7001_ $$aDunay, Ildiko R$$b6
000282546 7001_ $$aSchregel, Katharina$$b7
000282546 7001_ $$aGuttmann, Charles R G$$b8
000282546 7001_ $$aFuchs, Erelle$$b9
000282546 7001_ $$aBehme, Daniel$$b10
000282546 773__ $$0PERI:(DE-600)2041737-8$$a10.1016/j.sleep.2025.108663$$gVol. 137, p. 108663 -$$p108663$$tSleep medicine$$v137$$x1389-9457$$y2025
000282546 8564_ $$uhttps://pub.dzne.de/record/282546/files/DZNE-2025-01309.pdf$$yOpenAccess
000282546 8564_ $$uhttps://pub.dzne.de/record/282546/files/DZNE-2025-01309.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000282546 909CO $$ooai:pub.dzne.de:282546$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000282546 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9002802$$aExternal Institute$$b0$$kExtern
000282546 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002178$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000282546 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000282546 9141_ $$y2025
000282546 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-20
000282546 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000282546 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSLEEP MED : 2022$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000282546 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-20
000282546 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-20
000282546 9201_ $$0I:(DE-2719)1310010$$kAG Schreiber$$lMixed Cerebral Pathologies and Cognitive Aging$$x0
000282546 980__ $$ajournal
000282546 980__ $$aVDB
000282546 980__ $$aUNRESTRICTED
000282546 980__ $$aI:(DE-2719)1310010
000282546 9801_ $$aFullTexts