TY  - JOUR
AU  - Einspänner, Eric
AU  - Mattern, Hendrik
AU  - Grossmann, Heiko
AU  - Khadhraoui, Eya
AU  - Müller, Sebastian J
AU  - Garza, Alejandra P
AU  - Dunay, Ildiko R
AU  - Schregel, Katharina
AU  - Guttmann, Charles R G
AU  - Fuchs, Erelle
AU  - Behme, Daniel
TI  - A multimodal 7T MRI and biomarker study reveals reversible brain changes following acute sleep deprivation.
JO  - Sleep medicine
VL  - 137
SN  - 1389-9457
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2025-01309
SP  - 108663
PY  - 2025
AB  - Acute sleep deprivation is known to impair vigilance performance and alter brain physiology. This study investigates structural, physiological and cognitive effects of one night of sleep deprivation (SD) and subsequent recovery. Thirty healthy participants underwent (18M/12F, mean age 28.0 ± 4.7 years, range 20-38) a multimodal assessment including 7T MRI, plasma biomarker analysis, and Psychomotor Vigilance Task (PVT) testing at three time points: baseline, after 24 h of SD, and following a 72-h recovery period. Our results demonstrate that SD induced a significant increase in total perivascular space (PVS) volume (from 6711.5 mm3 to 7475.3 mm3; p < 0.001), a marker of impaired glymphatic function, which completely normalized after recovery. These macrostructural changes were accompanied by reversible microstructural alterations, including decreased T1 relaxation times and shifts in quantitative susceptibility mapping (QSM) in multiple brain regions, indicative of dynamic fluid shifts. Systemically, SD led to an increase in pro-inflammatory markers, notably MMP-9 (from 52.3 pg/mL to 69.2 pg/mL; p < 0.05), and changes in multiple peripheral biomarkers. Behaviorally, participants exhibited significantly more attentional lapses (slowest 10 
KW  - 7T MRI (Other)
KW  - Biomarkers (Other)
KW  - Neuroimaging (Other)
KW  - PVS (Other)
KW  - Sleep deprivation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41232306
DO  - DOI:10.1016/j.sleep.2025.108663
UR  - https://pub.dzne.de/record/282546
ER  -