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@ARTICLE{Einspnner:282546,
      author       = {Einspänner, Eric and Mattern, Hendrik and Grossmann, Heiko
                      and Khadhraoui, Eya and Müller, Sebastian J and Garza,
                      Alejandra P and Dunay, Ildiko R and Schregel, Katharina and
                      Guttmann, Charles R G and Fuchs, Erelle and Behme, Daniel},
      title        = {{A} multimodal 7{T} {MRI} and biomarker study reveals
                      reversible brain changes following acute sleep deprivation.},
      journal      = {Sleep medicine},
      volume       = {137},
      issn         = {1389-9457},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-01309},
      pages        = {108663},
      year         = {2025},
      abstract     = {Acute sleep deprivation is known to impair vigilance
                      performance and alter brain physiology. This study
                      investigates structural, physiological and cognitive effects
                      of one night of sleep deprivation (SD) and subsequent
                      recovery. Thirty healthy participants underwent (18M/12F,
                      mean age 28.0 ± 4.7 years, range 20-38) a multimodal
                      assessment including 7T MRI, plasma biomarker analysis, and
                      Psychomotor Vigilance Task (PVT) testing at three time
                      points: baseline, after 24 h of SD, and following a 72-h
                      recovery period. Our results demonstrate that SD induced a
                      significant increase in total perivascular space (PVS)
                      volume (from 6711.5 mm3 to 7475.3 mm3; p < 0.001), a marker
                      of impaired glymphatic function, which completely normalized
                      after recovery. These macrostructural changes were
                      accompanied by reversible microstructural alterations,
                      including decreased T1 relaxation times and shifts in
                      quantitative susceptibility mapping (QSM) in multiple brain
                      regions, indicative of dynamic fluid shifts. Systemically,
                      SD led to an increase in pro-inflammatory markers, notably
                      MMP-9 (from 52.3 pg/mL to 69.2 pg/mL; p < 0.05), and changes
                      in multiple peripheral biomarkers. Behaviorally,
                      participants exhibited significantly more attentional lapses
                      (slowest 10 $\%$ RT: 386.4 ms-410 ms; p < 0.05), which were
                      also reversed upon recovery. In conclusion, a single night
                      of SD triggers a cascade of interconnected and fully
                      reversible physiological changes, likely initiated by
                      transient glymphatic disruption. Healthy individuals are
                      able to recover mostly from one night of SD, suggesting that
                      adverse effects of SD, when not in a chronic state, can
                      potentially be reversed.},
      keywords     = {7T MRI (Other) / Biomarkers (Other) / Neuroimaging (Other)
                      / PVS (Other) / Sleep deprivation (Other)},
      cin          = {AG Schreiber},
      ddc          = {610},
      cid          = {I:(DE-2719)1310010},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41232306},
      doi          = {10.1016/j.sleep.2025.108663},
      url          = {https://pub.dzne.de/record/282546},
}