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000282554 0247_ $$2ISSN$$a1875-8908
000282554 037__ $$aDZNE-2025-01317
000282554 041__ $$aEnglish
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000282554 1001_ $$0P:(DE-2719)2241493$$aFink, Anne$$b0$$eFirst author
000282554 245__ $$aCan vigorous physical activity mitigate the effect of systemic inflammation on cognitive performance? Results from a large older community dwelling population in The Netherlands.
000282554 260__ $$aAmsterdam$$bIOS Press$$c2025
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000282554 520__ $$aBackgroundElevated systemic inflammation is associated with poorer cognitive function, while vigorous physical activity enhances cognition.ObjectiveThis study examines whether physical activity moderates the relationship between systemic inflammation and cognitive performance.MethodsWe analyzed 24,661 adults (50+) from the Dutch Lifelines cohort across two waves. Cognitive performance was assessed via a validated composite score from the Cogstate Brief Battery, with higher scores indicating lower cognitive performance. Leukocyte count (3-11 × 109 cells/liter) served as a systemic inflammation biomarker, categorized as low (<6.5 × 109 cells/liter) or high (≥6.5 × 109 cells/liter). We used the Short Questionnaire to Assess Health-Enhancing Physical Activity to define moderate (0, 1-149, 150+ minutes) and vigorous (0, 1-74, 75+ minutes) physical activity. We performed linear regression models to examine the effect of inflammation and vigorous physical activity on cognition, adjusting for moderate physical activity and covariates. An interaction effect analyzed the potential moderation of vigorous physical activity.ResultsIndividuals with high systemic inflammation (SI) levels in both waves exhibited significantly longer reaction times (b = 0.062 [95% confidence interval: 0.002; 0.122]) compared to those with low SI levels in both waves. Individuals who engaged in 1-74 min or 75+ minutes of vigorous physical activity had significantly faster reaction times (1-74: b = -0.114 [-0.193; -0.034], 75+: b = -0.160 [-0.210; -0.111]) than those who did not. The interaction term was insignificant.ConclusionsAlthough vigorous physical activity is protective, it cannot mitigate the negative association between systemic inflammation and cognition. Nevertheless, promoting vigorous physical activity in an ageing population can be an effective strategy for preventing or delaying cognitive decline.
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000282554 650_7 $$2Other$$aAlzheimer's disease
000282554 650_7 $$2Other$$acognitive performance
000282554 650_7 $$2Other$$acohort study
000282554 650_7 $$2Other$$aphysical activity
000282554 650_7 $$2Other$$asystemic inflammation
000282554 650_2 $$2MeSH$$aHumans
000282554 650_2 $$2MeSH$$aNetherlands: epidemiology
000282554 650_2 $$2MeSH$$aMale
000282554 650_2 $$2MeSH$$aFemale
000282554 650_2 $$2MeSH$$aInflammation: psychology
000282554 650_2 $$2MeSH$$aInflammation: epidemiology
000282554 650_2 $$2MeSH$$aExercise: physiology
000282554 650_2 $$2MeSH$$aExercise: psychology
000282554 650_2 $$2MeSH$$aAged
000282554 650_2 $$2MeSH$$aCognition: physiology
000282554 650_2 $$2MeSH$$aMiddle Aged
000282554 650_2 $$2MeSH$$aIndependent Living: psychology
000282554 650_2 $$2MeSH$$aCohort Studies
000282554 650_2 $$2MeSH$$aNeuropsychological Tests
000282554 650_2 $$2MeSH$$aCognitive Dysfunction
000282554 650_2 $$2MeSH$$aAged, 80 and over
000282554 650_2 $$2MeSH$$aAging in Place
000282554 7001_ $$00000-0003-3228-1794$$aReinke, Constantin$$b1
000282554 7001_ $$00000-0003-0143-0873$$aAretz, Benjamin$$b2
000282554 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T$$b3
000282554 7001_ $$0P:(DE-2719)2811246$$aDoblhammer, Gabriele$$b4$$eLast author
000282554 773__ $$0PERI:(DE-600)2070772-1$$a10.1177/13872877251386480$$gVol. 108, no. 3, p. 1369 - 1377$$n3$$p1369 - 1377$$tJournal of Alzheimer's disease$$v108$$x1387-2877$$y2025
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