TY  - JOUR
AU  - Fink, Anne
AU  - Reinke, Constantin
AU  - Aretz, Benjamin
AU  - Heneka, Michael T
AU  - Doblhammer, Gabriele
TI  - Can vigorous physical activity mitigate the effect of systemic inflammation on cognitive performance? Results from a large older community dwelling population in The Netherlands.
JO  - Journal of Alzheimer's disease
VL  - 108
IS  - 3
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2025-01317
SP  - 1369 - 1377
PY  - 2025
AB  - BackgroundElevated systemic inflammation is associated with poorer cognitive function, while vigorous physical activity enhances cognition.ObjectiveThis study examines whether physical activity moderates the relationship between systemic inflammation and cognitive performance.MethodsWe analyzed 24,661 adults (50+) from the Dutch Lifelines cohort across two waves. Cognitive performance was assessed via a validated composite score from the Cogstate Brief Battery, with higher scores indicating lower cognitive performance. Leukocyte count (3-11 × 109 cells/liter) served as a systemic inflammation biomarker, categorized as low (<6.5 × 109 cells/liter) or high (≥6.5 × 109 cells/liter). We used the Short Questionnaire to Assess Health-Enhancing Physical Activity to define moderate (0, 1-149, 150+ minutes) and vigorous (0, 1-74, 75+ minutes) physical activity. We performed linear regression models to examine the effect of inflammation and vigorous physical activity on cognition, adjusting for moderate physical activity and covariates. An interaction effect analyzed the potential moderation of vigorous physical activity.ResultsIndividuals with high systemic inflammation (SI) levels in both waves exhibited significantly longer reaction times (b = 0.062 [95
KW  - Humans
KW  - Netherlands: epidemiology
KW  - Male
KW  - Female
KW  - Inflammation: psychology
KW  - Inflammation: epidemiology
KW  - Exercise: physiology
KW  - Exercise: psychology
KW  - Aged
KW  - Cognition: physiology
KW  - Middle Aged
KW  - Independent Living: psychology
KW  - Cohort Studies
KW  - Neuropsychological Tests
KW  - Cognitive Dysfunction
KW  - Aged, 80 and over
KW  - Aging in Place
KW  - Alzheimer's disease (Other)
KW  - cognitive performance (Other)
KW  - cohort study (Other)
KW  - physical activity (Other)
KW  - systemic inflammation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41100846
C2  - pmc:PMC12647380
DO  - DOI:10.1177/13872877251386480
UR  - https://pub.dzne.de/record/282554
ER  -