guest ::
| Home > Publications Database > Transcriptional regulator SATB1 limits CD8+ T cell population expansion and effector differentiation in chronic infection and cancer. > print |
| Home > Publications Database > Transcriptional regulator SATB1 limits CD8+ T cell population expansion and effector differentiation in chronic infection and cancer. > print |
| 001 | 282555 | ||
| 005 | 20251219103449.0 | ||
| 024 | 7 | _ | |a 10.1038/s41590-025-02316-2 |2 doi |
| 024 | 7 | _ | |a pmid:41145844 |2 pmid |
| 024 | 7 | _ | |a 1529-2908 |2 ISSN |
| 024 | 7 | _ | |a 1529-2916 |2 ISSN |
| 037 | _ | _ | |a DZNE-2025-01318 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Heyden, Leonie |0 0009-0001-2018-8747 |b 0 |
| 245 | _ | _ | |a Transcriptional regulator SATB1 limits CD8+ T cell population expansion and effector differentiation in chronic infection and cancer. |
| 260 | _ | _ | |a London |c 2025 |b Springer Nature Limited |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1766050772_31259 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a CD8+ T cells are major mediators of antiviral and antitumor immunity. During persistent antigen stimulation as in chronic infection and cancer, however, they differentiate into exhausted T cells that display impaired functionality. Precursors of exhausted T (TPEX) cells exhibit stem-like properties, including high proliferative, self-renewal and developmental potential, and are responsible for long-term CD8+ T cell responses against persistent antigens. Here we identify the chromatin organizer and transcriptional regulator SATB1 as a major regulator of exhausted CD8+ T cell differentiation. SATB1 was specifically expressed in TPEX cells where it limited population expansion and effector differentiation while preserving functionality of CD8+ T cells. SATB1 downregulation was required for TPEX cell-to-effector cell differentiation in chronic infection and contributed to coordinated effector and memory differentiation in acute viral infection. DNA binding of SATB1 regulated gene expression both dependent and independent of chromatin accessibility. Finally, SATB1 limited antitumor CD8+ and chimeric antigen receptor T cell immunity. Overall, our results identify SATB1 as a central regulator of precursor fate and effector differentiation of CD8+ T cells both in infection and in cancer. |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 0 |
| 536 | _ | _ | |a 354 - Disease Prevention and Healthy Aging (POF4-354) |0 G:(DE-HGF)POF4-354 |c POF4-354 |f POF IV |x 1 |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 2 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Matrix Attachment Region Binding Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Satb1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a SATB1 protein, human |2 NLM Chemicals |
| 650 | _ | 2 | |a Matrix Attachment Region Binding Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Matrix Attachment Region Binding Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Matrix Attachment Region Binding Proteins: immunology |2 MeSH |
| 650 | _ | 2 | |a CD8-Positive T-Lymphocytes: immunology |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Cell Differentiation: immunology |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Immunologic Memory |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Neoplasms: immunology |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Persistent Infection: immunology |2 MeSH |
| 650 | _ | 2 | |a Lymphocytic Choriomeningitis: immunology |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a Cell Proliferation |2 MeSH |
| 650 | _ | 2 | |a Lymphocytic choriomeningitis virus: immunology |2 MeSH |
| 693 | _ | _ | |0 EXP:(DE-2719)PRECISE-20190321 |5 EXP:(DE-2719)PRECISE-20190321 |e Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn |x 0 |
| 700 | 1 | _ | |a Rausch, Lisa |b 1 |
| 700 | 1 | _ | |a Shannon, Michael H |0 0009-0006-4257-4629 |b 2 |
| 700 | 1 | _ | |a Dryburgh, Lachlan |0 0009-0007-5579-7466 |b 3 |
| 700 | 1 | _ | |a Moreira, Marcela L |0 0000-0003-3477-0727 |b 4 |
| 700 | 1 | _ | |a Frolov, Aleksej |0 P:(DE-2719)9002087 |b 5 |
| 700 | 1 | _ | |a Scheffler, Christina M |0 0000-0003-3731-6204 |b 6 |
| 700 | 1 | _ | |a van Elsas, Marit J |b 7 |
| 700 | 1 | _ | |a Tong, Junming |b 8 |
| 700 | 1 | _ | |a Hidajat, Olivia |b 9 |
| 700 | 1 | _ | |a Wijesinghe, Sharanya K M |0 0000-0002-0798-6226 |b 10 |
| 700 | 1 | _ | |a Li, Sining |0 0009-0001-4847-7153 |b 11 |
| 700 | 1 | _ | |a Horvatic, Helena |0 0000-0002-4188-4039 |b 12 |
| 700 | 1 | _ | |a Huynh-Anh, Nhat Truong |0 0009-0002-8152-8351 |b 13 |
| 700 | 1 | _ | |a Gago da Graça, Catarina |b 14 |
| 700 | 1 | _ | |a Tsui, Carlson |0 0000-0003-0642-814X |b 15 |
| 700 | 1 | _ | |a Köhne, Maren |0 P:(DE-2719)2812698 |b 16 |u dzne |
| 700 | 1 | _ | |a Sommer, Daniel |b 17 |
| 700 | 1 | _ | |a Wunderlich, F Thomas |b 18 |
| 700 | 1 | _ | |a von Scheidt, Bianca |b 19 |
| 700 | 1 | _ | |a Park, Simone L |b 20 |
| 700 | 1 | _ | |a Mackay, Laura K |0 0000-0002-8496-6632 |b 21 |
| 700 | 1 | _ | |a Utzschneider, Daniel T |0 0000-0003-2205-9057 |b 22 |
| 700 | 1 | _ | |a Schröder, Jan |b 23 |
| 700 | 1 | _ | |a Turner, Stephen J |0 0000-0002-1002-0000 |b 24 |
| 700 | 1 | _ | |a Darcy, Phillip K |0 0000-0002-5303-9561 |b 25 |
| 700 | 1 | _ | |a Beyer, Marc D |0 P:(DE-2719)2812219 |b 26 |
| 700 | 1 | _ | |a Abdullah, Zeinab |b 27 |
| 700 | 1 | _ | |a Kallies, Axel |0 0000-0002-6312-6968 |b 28 |
| 773 | _ | _ | |a 10.1038/s41590-025-02316-2 |g Vol. 26, no. 12, p. 2312 - 2327 |0 PERI:(DE-600)2026412-4 |n 12 |p 2312 - 2327 |t Nature immunology |v 26 |y 2025 |x 1529-2908 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/282555/files/DZNE-2025-01318%20SUP.zip |
| 856 | 4 | _ | |u https://pub.dzne.de/record/282555/files/DZNE-2025-01318.pdf |y Restricted |
| 856 | 4 | _ | |u https://pub.dzne.de/record/282555/files/DZNE-2025-01318.pdf?subformat=pdfa |x pdfa |y Restricted |
| 909 | C | O | |o oai:pub.dzne.de:282555 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 5 |6 P:(DE-2719)9002087 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 16 |6 P:(DE-2719)2812698 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 26 |6 P:(DE-2719)2812219 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-351 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Brain Function |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-354 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Prevention and Healthy Aging |x 1 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 2 |
| 914 | 1 | _ | |y 2025 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2024-12-13 |w ger |
| 915 | _ | _ | |a DEAL Nature |0 StatID:(DE-HGF)3003 |2 StatID |d 2024-12-13 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT IMMUNOL : 2022 |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2024-12-13 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2024-12-13 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2024-12-13 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2024-12-13 |
| 915 | _ | _ | |a IF >= 30 |0 StatID:(DE-HGF)9930 |2 StatID |b NAT IMMUNOL : 2022 |d 2024-12-13 |
| 920 | 1 | _ | |0 I:(DE-2719)1013035 |k AG Beyer |l Immunogenomics and Neurodegeneration |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1013038 |k AG Schultze |l Clinical Single Cell Omics (CSCO) / Systems Medicine |x 1 |
| 920 | 1 | _ | |0 I:(DE-2719)1013031 |k PRECISE |l Platform for Single Cell Genomics and Epigenomics |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1013035 |
| 980 | _ | _ | |a I:(DE-2719)1013038 |
| 980 | _ | _ | |a I:(DE-2719)1013031 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|