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@ARTICLE{Su:282556,
      author       = {Su, Julia and Gupta, Rohan and van Hoof, Scott and Kreye,
                      Jakob and Prüß, Harald and Spielman, Benjamin and
                      Brimberg, Lior and Volpe, Bruce T and Huerta, Patricio T and
                      Diamond, Betty},
      title        = {{H}eterogeneity of anti-{C}aspr2 antibodies: specificity
                      and pathogenicity.},
      journal      = {Translational Psychiatry},
      volume       = {15},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DZNE-2025-01319},
      pages        = {498},
      year         = {2025},
      abstract     = {Maternal anti-Caspr2 (Contactin-associated protein-like 2)
                      antibodies have been associated with increased risk for
                      autism spectrum disorder (ASD). Previous studies have shown
                      that in utero exposure to anti-Caspr2 antibodies results in
                      a phenotype with ASD-like features in male mice. Here we ask
                      whether four newly generated antibodies against Caspr2 are
                      pathogenic to the developing fetal brain and whether they
                      function through similar means. Our results show that these
                      novel anti-Caspr2 antibodies recognize different epitopes of
                      Caspr2. In utero exposure to these antibodies elicits
                      differential behavioral phenotypes in male offspring, as
                      demonstrated in the social interaction task, as well as
                      phenotypic alterations in the open-field and light-dark
                      tasks. These results demonstrate variability in the
                      antigenic specificity and pathogenicity of anti-Caspr2
                      antibodies which may have clinical implications.},
      keywords     = {Animals / Nerve Tissue Proteins: immunology / Male / Female
                      / Mice / Autism Spectrum Disorder: immunology / Membrane
                      Proteins: immunology / Pregnancy / Autoantibodies:
                      immunology / Prenatal Exposure Delayed Effects: immunology /
                      Behavior, Animal / Brain: immunology / Brain: embryology /
                      Humans / Nerve Tissue Proteins (NLM Chemicals) / Membrane
                      Proteins (NLM Chemicals) / Autoantibodies (NLM Chemicals) /
                      CNTNAP2 protein, mouse (NLM Chemicals)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41257955},
      pmc          = {pmc:PMC12644748},
      doi          = {10.1038/s41398-025-03677-w},
      url          = {https://pub.dzne.de/record/282556},
}