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@ARTICLE{Oomens:282559,
      author       = {Oomens, Julie E and Vos, Stephanie Jb and Maserejian, Nancy
                      N and Boada, Mercè and Didic, Mira and Engelborghs,
                      Sebastiaan and Fladby, Tormod and van der Flier, Wiesje M
                      and Frisoni, Giovanni B and Fröhlich, Lutz and Gill, Kiran
                      Dip and Grimmer, Timo and Hort, Jakub and Itoh, Yoshiaki and
                      Iwatsubo, Takeshi and Klimkowicz-Mrowiec, Aleksandra and
                      Landau, Susan M and Lee, Dong Young and Lleó, Alberto and
                      Martinez-Lage, Pablo and de Mendonça, Alexandre and Meyer,
                      Philipp T and Parchi, Piero and Pardini, Matteo and
                      Parnetti, Lucilla and Popp, Julius and Rami, Lorena and
                      Reiman, Eric M and Rinne, Juha O and Rodrigue, Karen M and
                      Sánchez-Juan, Pascual and Santana, Isabel and Scarmeas,
                      Nikolaos and Scheltens, Philip and Skoog, Ingmar and
                      Sperling, Reisa A and Stern, Yaakov and Villeneuve, Sylvia
                      and Waldemar, Gunhild and Wiltfang, Jens and Zetterberg,
                      Henrik and Alcolea, Daniel and Allegri, Ricardo F and
                      Altomare, Daniele and Bateman, Randall J and Baiardi, Simone
                      and Baldeiras, Ines and Blennow, Kaj and Braber, Anouk den
                      and van Buchem, Mark A and Byun, Min Soo and Cerman, Jiří
                      and Chen, Kewei and Chipi, Elena and Day, Gregory S and
                      Drzezga, Alexander and Ekblad, Laura L and Förster, Stefan
                      and Fortea, Juan and Freund-Levi, Yvonne and Frings, Lars
                      and Guedj, Eric and Habeck, Christian G and Handels, Ron and
                      Hausner, Lucrezia and Hellwig, Sabine and Jiménez-Bonilla,
                      Julio F and Juaristi, Ane Iriondo and Kandimalla, Ramesh and
                      Kern, Silke and Bordewick Kirsebom, Bjørn-Eivind S and
                      Kornhuber, Johannes and Legdeur, Nienke and Levin, Johannes
                      and Maier, Wolfgang and Marquié, Marta and Minatani,
                      Shinobu and Morbelli, Silvia Daniela and Mroczko, Barbara
                      and Ntanasi, Eva and de Oliveira, Catarina Resende and
                      Orellana, Adelina and Peters, Oliver and Prabhakar, Sudesh
                      and Ramakers, Inez H and Rodríguez-Rodriguez, Eloy and
                      Ruiz, Agustín and Rüther, Eckart and Sakhardande, Jayant
                      and Selnes, Per and Silva, Dina and Soininen, Hilkka and
                      Spiru, Luiza and Takeda, Akitoshi and Teunissen, Charlotte E
                      and Tijms, Betty M and Vermunt, Lisa and Wallin, Åsa K and
                      Wiels, Wietse and Yannakoulia, Mary and Yi, Dahyun and
                      Zettergren, Anna and Ossenkoppele, Rik and Verhey, Frans Rj
                      and Visser, Pieter Jelle and Jansen, Willemijn J},
      collaboration = {Initiative, Alzheimer's Disease Neuroimaging and group, A4
                      Study and Network, Dominantly Inherited Alzheimer and
                      Dementia, European Prevention of Alzheimer's and Disease,
                      Prediction of Alzheimer's and Disease, Presymptomatic
                      Evaluation of Experimental or Novel Treatments for
                      Alzheimer's and Early Diagnosis},
      othercontributors = {Japan Alzheimer's Disease Neuroimaging Initiative , Korean
                          Brain Aging Study},
      title        = {{A}ssociations of lifestyle factors with amyloid pathology
                      in persons without dementia.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {108},
      number       = {3},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2025-01322},
      pages        = {1043 - 1059},
      year         = {2025},
      abstract     = {BackgroundThe association between lifestyle factors and
                      Alzheimer's disease (AD) pathophysiology remains
                      incompletely understood.ObjectiveThe aim of this study was
                      to assess the association of alcohol consumption, smoking
                      behavior, sleep quality and physical, cognitive, and social
                      activity with cerebral amyloid pathology.MethodsFor this
                      cross-sectional study, we selected participants from the
                      Amyloid Biomarker Study data pooling initiative. We used
                      generalized estimating equations to assess associations of
                      dichotomized lifestyle measures with amyloid
                      pathology.ResultsWe included 9171 participants with normal
                      cognition (NC) and 2555 participants with mild cognitive
                      impairment (MCI) from the Amyloid Biomarker Study. Of
                      participants with NC, $58\%$ were women, $34\%$ were APOE
                      ε4 carrier, and $27\%$ had amyloid pathology. Of
                      participants with MCI, $48\%$ were women, $47\%$ were APOE
                      ε4 carrier, and $57\%$ had amyloid pathology. In NC,
                      cognitively active participants were less likely to have
                      amyloid pathology (OR = 0.77, $95\%CI$ 0.66-0.89, p <
                      0.001). In MCI, participants who had ever smoked or had
                      sleep problems were less likely to have amyloid pathology
                      (OR = 0.85, $95\%CI$ 0.73-0.99, p = 0.029; OR = 0.62,
                      $95\%CI$ 0.45-0.86, p = 0.004).ConclusionsIn NC, cognitive
                      activity was associated with a lower frequency of amyloid
                      pathology. In MCI, favorable lifestyle behaviors were not
                      associated with a lower frequency of amyloid pathology. The
                      results of the current study contribute to the broader
                      evidence base on lifestyle and AD by further characterizing
                      the role of lifestyle behaviors in AD pathology across
                      different clinical stages.},
      keywords     = {Humans / Female / Male / Aged / Life Style /
                      Cross-Sectional Studies / Cognitive Dysfunction: pathology /
                      Cognitive Dysfunction: psychology / Cognitive Dysfunction:
                      metabolism / Cognitive Dysfunction: genetics / Aged, 80 and
                      over / Alcohol Drinking / Smoking / Middle Aged / Amyloid:
                      metabolism / Apolipoprotein E4: genetics / Dementia /
                      Alzheimer's disease (Other) / amyloid (Other) / amyloid
                      biomarker study (Other) / cerebrospinal fluid (Other) /
                      lifestyle (Other) / positron emission tomography (Other) /
                      Amyloid (NLM Chemicals) / Apolipoprotein E4 (NLM Chemicals)},
      cin          = {Clinical Research (Munich) / AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015 / I:(DE-2719)1111016},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41234025},
      pmc          = {pmc:PMC12647378},
      doi          = {10.1177/13872877251379083},
      url          = {https://pub.dzne.de/record/282559},
}