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001     282559
005     20251202141200.0
024 7 _ |a 10.1177/13872877251379083
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024 7 _ |a pmid:41234025
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024 7 _ |a pmc:PMC12647378
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024 7 _ |a 1387-2877
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024 7 _ |a 1875-8908
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037 _ _ |a DZNE-2025-01322
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Oomens, Julie E
|b 0
245 _ _ |a Associations of lifestyle factors with amyloid pathology in persons without dementia.
260 _ _ |a Amsterdam
|c 2025
|b IOS Press
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.MethodsFor this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.ResultsWe included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66-0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004).ConclusionsIn NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.
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650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a amyloid
|2 Other
650 _ 7 |a amyloid biomarker study
|2 Other
650 _ 7 |a cerebrospinal fluid
|2 Other
650 _ 7 |a lifestyle
|2 Other
650 _ 7 |a positron emission tomography
|2 Other
650 _ 7 |a Amyloid
|2 NLM Chemicals
650 _ 7 |a Apolipoprotein E4
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Life Style
|2 MeSH
650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: psychology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: metabolism
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: genetics
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Alcohol Drinking
|2 MeSH
650 _ 2 |a Smoking
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Amyloid: metabolism
|2 MeSH
650 _ 2 |a Apolipoprotein E4: genetics
|2 MeSH
650 _ 2 |a Dementia
|2 MeSH
700 1 _ |a Vos, Stephanie Jb
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700 1 _ |a Maserejian, Nancy N
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700 1 _ |a Boada, Mercè
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700 1 _ |a Didic, Mira
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700 1 _ |a Engelborghs, Sebastiaan
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700 1 _ |a Fladby, Tormod
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700 1 _ |a van der Flier, Wiesje M
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700 1 _ |a Frisoni, Giovanni B
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700 1 _ |a Fröhlich, Lutz
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700 1 _ |a Gill, Kiran Dip
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700 1 _ |a Grimmer, Timo
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700 1 _ |a Hort, Jakub
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700 1 _ |a Itoh, Yoshiaki
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700 1 _ |a Iwatsubo, Takeshi
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700 1 _ |a Klimkowicz-Mrowiec, Aleksandra
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700 1 _ |a Landau, Susan M
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700 1 _ |a Lee, Dong Young
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700 1 _ |a Lleó, Alberto
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700 1 _ |a Martinez-Lage, Pablo
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700 1 _ |a de Mendonça, Alexandre
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700 1 _ |a Meyer, Philipp T
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700 1 _ |a Parchi, Piero
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700 1 _ |a Pardini, Matteo
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700 1 _ |a Parnetti, Lucilla
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700 1 _ |a Popp, Julius
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700 1 _ |a Rami, Lorena
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700 1 _ |a Reiman, Eric M
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700 1 _ |a Rinne, Juha O
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700 1 _ |a Rodrigue, Karen M
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700 1 _ |a Sánchez-Juan, Pascual
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700 1 _ |a Santana, Isabel
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700 1 _ |a Scarmeas, Nikolaos
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700 1 _ |a Scheltens, Philip
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700 1 _ |a Skoog, Ingmar
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700 1 _ |a Sperling, Reisa A
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700 1 _ |a Stern, Yaakov
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700 1 _ |a Villeneuve, Sylvia
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700 1 _ |a Waldemar, Gunhild
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700 1 _ |a Wiltfang, Jens
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700 1 _ |a Zetterberg, Henrik
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700 1 _ |a Alcolea, Daniel
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700 1 _ |a Allegri, Ricardo F
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700 1 _ |a Altomare, Daniele
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700 1 _ |a Bateman, Randall J
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700 1 _ |a Baiardi, Simone
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700 1 _ |a Baldeiras, Ines
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700 1 _ |a Blennow, Kaj
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700 1 _ |a Braber, Anouk den
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700 1 _ |a van Buchem, Mark A
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700 1 _ |a Byun, Min Soo
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700 1 _ |a Cerman, Jiří
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700 1 _ |a Chen, Kewei
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700 1 _ |a Chipi, Elena
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700 1 _ |a Day, Gregory S
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700 1 _ |a Ekblad, Laura L
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700 1 _ |a Förster, Stefan
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700 1 _ |a Fortea, Juan
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700 1 _ |a Freund-Levi, Yvonne
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700 1 _ |a Frings, Lars
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700 1 _ |a Guedj, Eric
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700 1 _ |a Habeck, Christian G
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700 1 _ |a Handels, Ron
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700 1 _ |a Hausner, Lucrezia
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700 1 _ |a Hellwig, Sabine
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700 1 _ |a Jiménez-Bonilla, Julio F
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700 1 _ |a Juaristi, Ane Iriondo
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700 1 _ |a Kandimalla, Ramesh
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700 1 _ |a Kern, Silke
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700 1 _ |a Bordewick Kirsebom, Bjørn-Eivind S
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700 1 _ |a Kornhuber, Johannes
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700 1 _ |a Legdeur, Nienke
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700 1 _ |a Levin, Johannes
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700 1 _ |a Maier, Wolfgang
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700 1 _ |a Marquié, Marta
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700 1 _ |a Minatani, Shinobu
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700 1 _ |a Morbelli, Silvia Daniela
|b 77
700 1 _ |a Mroczko, Barbara
|b 78
700 1 _ |a Ntanasi, Eva
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700 1 _ |a de Oliveira, Catarina Resende
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700 1 _ |a Orellana, Adelina
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700 1 _ |a Peters, Oliver
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700 1 _ |a Prabhakar, Sudesh
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700 1 _ |a Ramakers, Inez H
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700 1 _ |a Rodríguez-Rodriguez, Eloy
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700 1 _ |a Ruiz, Agustín
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700 1 _ |a Rüther, Eckart
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700 1 _ |a Sakhardande, Jayant
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700 1 _ |a Selnes, Per
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700 1 _ |a Silva, Dina
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700 1 _ |a Soininen, Hilkka
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700 1 _ |a Spiru, Luiza
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700 1 _ |a Takeda, Akitoshi
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700 1 _ |a Teunissen, Charlotte E
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700 1 _ |a Tijms, Betty M
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700 1 _ |a Vermunt, Lisa
|b 96
700 1 _ |a Wallin, Åsa K
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700 1 _ |a Wiels, Wietse
|b 98
700 1 _ |a Yannakoulia, Mary
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700 1 _ |a Yi, Dahyun
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700 1 _ |a Zettergren, Anna
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700 1 _ |a Initiative, Alzheimer's Disease Neuroimaging
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700 1 _ |a group, A4 Study
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700 1 _ |a Network, Dominantly Inherited Alzheimer
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700 1 _ |a Dementia, European Prevention of Alzheimer's
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700 1 _ |a Japan Alzheimer's Disease Neuroimaging Initiative , Korean Brain Aging Study
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700 1 _ |a Disease, Prediction of Alzheimer's
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700 1 _ |a Disease, Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's
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700 1 _ |a Ossenkoppele, Rik
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700 1 _ |a Verhey, Frans Rj
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700 1 _ |a Visser, Pieter Jelle
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700 1 _ |a Jansen, Willemijn J
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700 1 _ |a Early Diagnosis
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773 _ _ |a 10.1177/13872877251379083
|g Vol. 108, no. 3, p. 1043 - 1059
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