TY  - JOUR
AU  - Beeke, M.
AU  - Sauer, C.
AU  - Petzold, J.
AU  - Schneider, S.
AU  - Frenzen, K.
AU  - Donix, M.
AU  - Reiß, G.
AU  - Brandt, Daniel Moritz
AU  - Haußmann, R.
TI  - Beobachtungsstudie zur Koinzidenz von Alzheimer-Erkrankung und idiopathischem Normaldruckhydrozephalus: Analyse von Koinzidenz, deren Einfluss auf das Ansprechen im Liquorablassversuch und zerebrovaskulärer Kopathologie  -  Observational study on the coincidence of Alzheimer's disease and idiopathic normal pressure hydrocephalus: analysis of coincidence, the influence on response to cerebrospinal fluid drainage and cerebrovascular copathology
JO  - Der Nervenarzt
VL  - 96
IS  - 7
SN  - 0028-2804
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2025-01327
SP  - 686 - 695
PY  - 2025
AB  - Analysis of the frequency of comorbid Alzheimer's disease in patients with suspected idiopathic normal pressure hydrocephalus (iNPH) and its effects on the response to cerebrospinal fluid (CSF) drainage as well as analysis of the frequency of a vascular copathology in patients with suspected iNPH.This was a prospective observational analysis of patients with suspected iNPH who underwent guideline-conform NPH routine diagnostics including CSF drainage during clinical routine diagnostics between 1 July 2022 and 30 June 2023. Patients were recruited via the departments of neurology, neurosurgery and psychiatry of the University Hospital Carl Gustav Carus in Dresden. Typical NPH imaging results were acquired from available magnetic resonance imaging (MRI) and computed tomography (CT) sectional images. Relevant sociodemographic, clinical, cognitive and CSF diagnostic parameters were acquired via patient chart review. The patients were categorized with respect to the CSF results according to the amyloid-tau-neurodegeneration (ATN) classification.During the observational period 33 patients (14 female, 19 male, mean age 74.6 ± 8.1 years) with suspected iNPH were analyzed. Of the patients 19 (57.6
KW  - Humans
KW  - Hydrocephalus, Normal Pressure: epidemiology
KW  - Hydrocephalus, Normal Pressure: therapy
KW  - Hydrocephalus, Normal Pressure: diagnosis
KW  - Hydrocephalus, Normal Pressure: cerebrospinal fluid
KW  - Hydrocephalus, Normal Pressure: complications
KW  - Female
KW  - Male
KW  - Aged
KW  - Alzheimer Disease: epidemiology
KW  - Alzheimer Disease: cerebrospinal fluid
KW  - Alzheimer Disease: diagnosis
KW  - Alzheimer Disease: complications
KW  - Alzheimer Disease: therapy
KW  - Aged, 80 and over
KW  - Prospective Studies
KW  - Magnetic Resonance Imaging
KW  - Drainage
KW  - Comorbidity
KW  - Middle Aged
KW  - Corpus callosum angle (Other)
KW  - Evans index (Other)
KW  - Hakim’s triad (Other)
KW  - Spinal drainage (Other)
KW  - Vascular copathology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40016477
C2  - pmc:PMC12662853
DO  - DOI:10.1007/s00115-025-01808-8
UR  - https://pub.dzne.de/record/282564
ER  -