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000282575 1001_ $$0P:(DE-2719)9003256$$aHeld, Nina Rebecca$$b0$$udzne
000282575 245__ $$aQuantitative susceptibility mapping at 7T as a biomarker of post- and interictal extravascular iron in patients with focal epilepsy.
000282575 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2025
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000282575 520__ $$aIron deposition in the brain has been associated with epilepsy, but its anatomical distribution and its temporal association to seizures remain unclear. Here, we investigate brain iron in individuals with focal epilepsy using interictal and postictal quantitative susceptibility mapping (QSM) at 7 T MRI and explore its functional relevance.80 consecutive participants with focal epilepsy undergoing presurgical evaluation and 50 healthy controls were included. 8/80 participants with focal epilepsy had interictal and postictal scans. High-resolution T1- and susceptibility-weighted images were acquired and processed using custom pipelines for QSM. Seizure onset zones were determined by expert consensus, and neuropsychological assessments included memory and mood. Parcel-wise analyses examined group differences and correlations with cognitive scores, controlling for age and sex.Participants with focal epilepsy showed significantly higher interictal susceptibility, which colocalised with the presumed seizure onset zone. Impaired memory performance and more severe depressive symptoms were correlated with higher interictal susceptibility. Postictal susceptibility was significantly higher than interictal susceptibility and associated to the number of preceding seizures.QSM reflects both ictal iron extravasation and interictal iron accumulation. If further validated, it may help to non-invasively delineate the epileptogenic zone and become a long-term biomarker for seizure-burden.N.R.H. and T.Bauer were supported by the BONFOR research commission of the Medical Faculty of the University of Bonn. T.Bauer was funded by the Deutsche Forschungsgemeinschaft. T.Bauer., L.W., A.L. and T.R. are funded by the German Ministry for Research, Technology and Space.
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000282575 650_7 $$2Other$$aBlood–brain-barrier dysfunction
000282575 650_7 $$2Other$$aNeuroinflammation
000282575 650_7 $$2Other$$aPostictal imaging
000282575 650_7 $$2Other$$aUltra-high-field MRI
000282575 7001_ $$0P:(DE-2719)9002598$$aBauer, Tobias$$b1$$udzne
000282575 7001_ $$0P:(DE-2719)2810697$$aStirnberg, Rüdiger$$b2$$udzne
000282575 7001_ $$aRecke, Theda von der$$b3
000282575 7001_ $$aLehnen, Nils Christian$$b4
000282575 7001_ $$aBaumgartner, Tobias$$b5
000282575 7001_ $$aWitt, Juri-Alexander$$b6
000282575 7001_ $$aRácz, Attila$$b7
000282575 7001_ $$aPukropski, Jan$$b8
000282575 7001_ $$aWalger, Lennart$$b9
000282575 7001_ $$avon Wrede, Randi$$b10
000282575 7001_ $$aBadr, Mostafa$$b11
000282575 7001_ $$aWolf, David$$b12
000282575 7001_ $$aKersting, Lennart Nils$$b13
000282575 7001_ $$aLange, Annalena$$b14
000282575 7001_ $$aBisten, Justus$$b15
000282575 7001_ $$aSchmidt, Markus$$b16
000282575 7001_ $$0P:(DE-2719)2810559$$aPracht, Eberhard$$b17$$udzne
000282575 7001_ $$0P:(DE-2719)9001317$$aLöwen, Daniel$$b18$$udzne
000282575 7001_ $$0P:(DE-2719)2811327$$aFaber, Jennifer$$b19$$udzne
000282575 7001_ $$aHelmstaedter, Christoph$$b20
000282575 7001_ $$0P:(DE-2719)2812134$$aReuter, Martin$$b21$$udzne
000282575 7001_ $$aFriedman, Alon$$b22
000282575 7001_ $$0P:(DE-2719)9001861$$aRadbruch, Alexander$$b23$$udzne
000282575 7001_ $$aSurges, Rainer$$b24
000282575 7001_ $$0P:(DE-2719)2810538$$aStöcker, Tony$$b25$$udzne
000282575 7001_ $$0P:(DE-HGF)0$$aRüber, Theodor$$b26$$eLast author
000282575 773__ $$0PERI:(DE-600)2799017-5$$a10.1016/j.ebiom.2025.106040$$gVol. 122, p. 106040 -$$p106040$$tEBioMedicine$$v122$$x2352-3964$$y2025
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