%0 Journal Article
%A Halbgebauer, Steffen
%A Fazeli, Badrieh
%A Klose, Veronika
%A Nagel, Gabriele
%A Rosenbohm, Angela
%A Rothenbacher, Dietrich
%A Bachhuber, Franziska
%A Jesse, Sarah
%A Otto, Markus
%A Landwehrmeyer, Georg Bernhard
%A Abdelhak, Ahmed
%A Petzold, Axel
%A Ludolph, Albert C
%A Tumani, Hayrettin
%T Age-Specific Control and Alzheimer Disease Reference Curves and z-Scores for Glial Fibrillary Acidic Protein in Blood.
%J Clinical chemistry
%V 71
%N 12
%@ 0009-9147
%C Washington, DC
%I American Association for Clinical Chemistry
%M DZNE-2025-01337
%P 1234 - 1242
%D 2025
%X Serum glial fibrillary acidic protein (GFAP) is a biomarker for astrocytic injury and astrogliosis. Concentrations are elevated in numerous neurological disorders, including a pronounced increase in Alzheimer disease (AD). However, GFAP levels in the serum also increase with age. Consequently, the integration of GFAP levels into clinical routine and their interpretation demands age-adjusted reference values.Serum from 1273 subjects (952 noninflammatory and nonneurodegenerative neurological controls and 321 subjects with AD) was analyzed for GFAP using the microfluidic Ella system. Age-dependent serum GFAP reference values were estimated by additive quantile regression analysis and visualized with percentiles and z-scores.AD exhibited elevated serum GFAP levels in comparison to control patients (P < 0.0001). This remained the case when the newly generated age-corrected z-scores were applied (P < 0.0001). In the control cohort, a nonlinear elevation of serum GFAP with increasing age was observed (Spearman correlation coefficient 0.62, 95
%K Humans
%K Alzheimer Disease: blood
%K Alzheimer Disease: diagnosis
%K Glial Fibrillary Acidic Protein: blood
%K Aged
%K Male
%K Female
%K Middle Aged
%K Reference Values
%K Biomarkers: blood
%K Aged, 80 and over
%K Age Factors
%K Adult
%K Case-Control Studies
%K Glial Fibrillary Acidic Protein (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K GFAP protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41081630
%R 10.1093/clinchem/hvaf120
%U https://pub.dzne.de/record/282577