TY  - JOUR
AU  - Halbgebauer, Steffen
AU  - Fazeli, Badrieh
AU  - Klose, Veronika
AU  - Nagel, Gabriele
AU  - Rosenbohm, Angela
AU  - Rothenbacher, Dietrich
AU  - Bachhuber, Franziska
AU  - Jesse, Sarah
AU  - Otto, Markus
AU  - Landwehrmeyer, Georg Bernhard
AU  - Abdelhak, Ahmed
AU  - Petzold, Axel
AU  - Ludolph, Albert C
AU  - Tumani, Hayrettin
TI  - Age-Specific Control and Alzheimer Disease Reference Curves and z-Scores for Glial Fibrillary Acidic Protein in Blood.
JO  - Clinical chemistry
VL  - 71
IS  - 12
SN  - 0009-9147
CY  - Washington, DC
PB  - American Association for Clinical Chemistry
M1  - DZNE-2025-01337
SP  - 1234 - 1242
PY  - 2025
AB  - Serum glial fibrillary acidic protein (GFAP) is a biomarker for astrocytic injury and astrogliosis. Concentrations are elevated in numerous neurological disorders, including a pronounced increase in Alzheimer disease (AD). However, GFAP levels in the serum also increase with age. Consequently, the integration of GFAP levels into clinical routine and their interpretation demands age-adjusted reference values.Serum from 1273 subjects (952 noninflammatory and nonneurodegenerative neurological controls and 321 subjects with AD) was analyzed for GFAP using the microfluidic Ella system. Age-dependent serum GFAP reference values were estimated by additive quantile regression analysis and visualized with percentiles and z-scores.AD exhibited elevated serum GFAP levels in comparison to control patients (P < 0.0001). This remained the case when the newly generated age-corrected z-scores were applied (P < 0.0001). In the control cohort, a nonlinear elevation of serum GFAP with increasing age was observed (Spearman correlation coefficient 0.62, 95
KW  - Humans
KW  - Alzheimer Disease: blood
KW  - Alzheimer Disease: diagnosis
KW  - Glial Fibrillary Acidic Protein: blood
KW  - Aged
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Reference Values
KW  - Biomarkers: blood
KW  - Aged, 80 and over
KW  - Age Factors
KW  - Adult
KW  - Case-Control Studies
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - GFAP protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41081630
DO  - DOI:10.1093/clinchem/hvaf120
UR  - https://pub.dzne.de/record/282577
ER  -