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@ARTICLE{Doblhammer:282581,
      author       = {Doblhammer, Gabriele and Erlangsen, Annette and Fink, Anne
                      and Canudas-Romo, Vladimir},
      title        = {{D}eclining incidence but little change in years lived with
                      dementia in two {G}erman cohorts diagnosed with dementia in
                      2006/2008 and 2016/2018.},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {17},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2025-01341},
      pages        = {255},
      year         = {2025},
      abstract     = {We examined whether changes in dementia incidence and
                      mortality have led to changes in the average number of years
                      lived with and without dementia over a ten-year period in
                      Germany.We calculated dementia rates using two samples of
                      people aged 65 + from a German health insurance company,
                      each comprising more than 100,000 people in 2006/08 and
                      2016/18. We examined time trends using negative binomial
                      regression models and estimated average life expectancy
                      (ALE) for people with and without dementia by fitting a
                      three-stage Markov health-disease model.Dementia incidence
                      rates decreased by $7.3\%$ in men and by $9.7\%$ in women.
                      Dementia mortality rates fell by $12\%$ in men but did not
                      change significantly in women. Non-dementia mortality rates
                      fell by $7\%$ in both men and women. The combined changes
                      resulted in stable total ALE in men and increasing total ALE
                      in women, whereas ALE with dementia increased in men and
                      remained stable in women.The observed decline in dementia
                      incidence did not translate into a reduction in the burden
                      of the disease.The online version contains supplementary
                      material available at 10.1186/s13195-025-01911-7.},
      keywords     = {Dementia incidence (Other) / Dementia mortality (Other) /
                      Germany (Other) / Life expectancy (Other) / Time trends
                      (Other)},
      cin          = {AG Doblhammer},
      ddc          = {610},
      cid          = {I:(DE-2719)1012002},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41331692},
      pmc          = {pmc:PMC12670842},
      doi          = {10.1186/s13195-025-01911-7},
      url          = {https://pub.dzne.de/record/282581},
}