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000282584 1001_ $$00000-0002-2095-3488$$aWillemse, Ilse H J$$b0
000282584 245__ $$aFeasibility of a smartphone application for remote use in spastic ataxias: an 8-week long-term PROSPAX study.
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000282584 520__ $$aDigital biomarkers show significant potential and are emerging as outcome measures in clinical trials in spastic ataxias (SPAX). Research on the performances of digital biomarkers in home environments remains limited.To evaluate feasibility, user adherence, time-of-day and learning effects, and consistency across settings of the SPAX-app for home monitoring in clinical trials. The app contains four tasks assessing gait, standing balance, and finger and hand movements, along with a patient-reported outcome measure (PROM).We conducted an 8-week long-term study in 38 SPAX patients and 10 healthy controls. Subjects first answered the SPAX-app PROM and performed tasks during one in-clinic session. Severity of ataxia and spasticity were assessed by clinician-reported outcome measures (ClinROs). Subjects then performed the tasks and answered the PROM twice a week in the morning and evening at home.The SPAX-app showed high feasibility for finger and hand movement tasks (92%), but limited feasibility for gait (47%) and stance (63%) tasks. Among those able to perform the tasks, adherence was high (81%). A significant difference (p < 0.01) was found between morning and evening assessments by PROMs in SPAX. Results remained stable across the day and repeated assessments, except for the inter-onset interval in finger tapping (p = 0.002 and p = 0.020, respectively). Strong correlations were observed between tasks performed at home and in the clinic. Motor outcome measures correlated well with ClinROs, but not with PROMs.The SPAX-app is a feasible tool for remote assessment in SPAX, showing high feasibility for finger and hand movement tasks, but limited feasibility for gait and stance tasks at home. Time-of-day and learning effects were minimal. Longer-term studies are needed to assess clinical relevance.
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000282584 650_7 $$2Other$$aDigital biomarkers
000282584 650_7 $$2Other$$aLong-term study
000282584 650_7 $$2Other$$aRemote monitoring
000282584 650_7 $$2Other$$aSmartphone application
000282584 650_7 $$2Other$$aSpastic ataxia
000282584 650_2 $$2MeSH$$aHumans
000282584 650_2 $$2MeSH$$aMale
000282584 650_2 $$2MeSH$$aFemale
000282584 650_2 $$2MeSH$$aFeasibility Studies
000282584 650_2 $$2MeSH$$aMiddle Aged
000282584 650_2 $$2MeSH$$aAdult
000282584 650_2 $$2MeSH$$aSmartphone
000282584 650_2 $$2MeSH$$aMobile Applications
000282584 650_2 $$2MeSH$$aMuscle Spasticity: diagnosis
000282584 650_2 $$2MeSH$$aMuscle Spasticity: physiopathology
000282584 650_2 $$2MeSH$$aAged
000282584 650_2 $$2MeSH$$aPatient Reported Outcome Measures
000282584 650_2 $$2MeSH$$aLongitudinal Studies
000282584 650_2 $$2MeSH$$aPostural Balance: physiology
000282584 650_2 $$2MeSH$$aYoung Adult
000282584 7001_ $$aMellone, Sabato$$b1
000282584 7001_ $$aTacconi, Carlo$$b2
000282584 7001_ $$aSantorelli, Filippo M$$b3
000282584 7001_ $$aRicca, Ivana$$b4
000282584 7001_ $$aSatolli, Sara$$b5
000282584 7001_ $$aKlebe, Stephan$$b6
000282584 7001_ $$aJeschonneck, Nicole$$b7
000282584 7001_ $$aIlg, Winfried$$b8
000282584 7001_ $$0P:(DE-2719)2812018$$aSchüle-Freyer, Rebecca$$b9$$udzne
000282584 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b10$$udzne
000282584 7001_ $$aNonnekes, Jorik$$b11
000282584 7001_ $$avan de Warrenburg, Bart P C$$b12
000282584 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-025-13514-1$$gVol. 273, no. 1, p. 3$$n1$$p3$$tJournal of neurology$$v273$$x0367-004X$$y2025
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