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000282586 041__ $$aEnglish
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000282586 1001_ $$0P:(DE-2719)9002283$$avon Danwitz, Niklas M$$b0$$eFirst author
000282586 245__ $$aPatterns and predictors of delayed functional independence and dependence after thrombectomy in large vessel occlusion stroke: A multicenter analysis.
000282586 260__ $$aLondon$$bSage Publishing$$c2025
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000282586 520__ $$aPredicting functional outcomes following endovascular treatment (EVT) for large-vessel occlusion stroke (LVOS) is challenging. Some patients achieve functional independence (modified Rankin Scale (mRS) 0 -2) at 90 days despite being dependent at discharge, termed delayed functional independence (DFI), while others lose independence after discharge, termed delayed functional dependence (DFD). This study explores patterns and predictors of DFI and DFD in LVOS patients undergoing EVT.We analyzed anterior circulation LVOS patients from the prospective multicenter German Stroke Registry. Multivariable logistic regression models identified independent predictors of DFI and DFD.Of 5909 patients, 2346 were independent at discharge, with 16.1% experiencing DFD at 90 days. DFD was associated with older age (median 78 vs 69 years, p < 0.001), female sex (61.4% vs 46.1%, p < 0.001), and greater stroke severity. Variables associated with DFD in multivariable analysis included older age, female sex, higher premorbid and discharge mRS, higher NIHSS at discharge, and absence of IV thrombolysis. Of 3563 patients dependent at discharge, 20.6% achieved DFI. DFI patients were younger (median 71 vs 77 years, p < 0.001), less likely female (38.7% vs 52.6%, p < 0.001) and had lower admission NIHSS, better pre-stroke functional status, higher ASPECTS and more frequent successful recanalization. Variables associated with DFI in multivariable analysis included younger age, male sex, better pre-stroke functional status, lower stroke severity and successful recanalization.Both DFD and DFI are frequent in clinical practice, with higher DFD and lower DFI rates in women, which warrants further investigation. Understanding these predictors can enhance individualized patient counseling and management strategies.
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000282586 650_7 $$2Other$$aStroke
000282586 650_7 $$2Other$$adelayed dependence
000282586 650_7 $$2Other$$aendovascular treatment
000282586 650_7 $$2Other$$afunctional dependence
000282586 650_7 $$2Other$$afunctional independence
000282586 650_7 $$2Other$$amechanical thrombectomy
000282586 650_7 $$2Other$$aoutcome
000282586 650_2 $$2MeSH$$aHumans
000282586 650_2 $$2MeSH$$aFemale
000282586 650_2 $$2MeSH$$aMale
000282586 650_2 $$2MeSH$$aAged
000282586 650_2 $$2MeSH$$aThrombectomy: methods
000282586 650_2 $$2MeSH$$aAged, 80 and over
000282586 650_2 $$2MeSH$$aMiddle Aged
000282586 650_2 $$2MeSH$$aTreatment Outcome
000282586 650_2 $$2MeSH$$aRecovery of Function
000282586 650_2 $$2MeSH$$aRegistries
000282586 650_2 $$2MeSH$$aIschemic Stroke: surgery
000282586 650_2 $$2MeSH$$aFunctional Status
000282586 650_2 $$2MeSH$$aProspective Studies
000282586 650_2 $$2MeSH$$aEndovascular Procedures
000282586 650_2 $$2MeSH$$aStroke: surgery
000282586 650_2 $$2MeSH$$aGermany
000282586 7001_ $$0P:(DE-2719)2811949$$aBode, Felix J$$b1
000282586 7001_ $$0P:(DE-2719)9002936$$aSamani, Omid Shirvani$$b2
000282586 7001_ $$0P:(DE-2719)9003181$$aAsperger, Hannah$$b3$$udzne
000282586 7001_ $$0P:(DE-2719)9003076$$aEbrahimi, Taraneh$$b4
000282586 7001_ $$aKaesmacher, Johannes$$b5
000282586 7001_ $$00000-0001-5904-5316$$aLayer, Julia$$b6
000282586 7001_ $$aLehnen, Nils$$b7
000282586 7001_ $$aNitsch, Louisa$$b8
000282586 7001_ $$00000-0002-8980-9337$$aMeissner, Julius N$$b9
000282586 7001_ $$aOdensass, Svenja$$b10
000282586 7001_ $$0P:(DE-2719)9000778$$aStösser, Sebastian$$b11$$udzne
000282586 7001_ $$0P:(DE-2719)9002386$$aThielscher, Christian$$b12$$udzne
000282586 7001_ $$00000-0002-5236-3992$$aZidan, Mousa$$b13
000282586 7001_ $$aDorn, Franziska$$b14
000282586 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b15$$udzne
000282586 7001_ $$00000-0001-5818-5392$$aWeller, Johannes M$$b16
000282586 773__ $$0PERI:(DE-600)2851287-X$$a10.1177/23969873251342048$$gVol. 10, no. 4, p. 1292 - 1299$$n4$$p1292 - 1299$$tEuropean stroke journal$$v10$$x2396-9873$$y2025
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