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@ARTICLE{Schroeter:282596,
      author       = {Schroeter, Matthias L and Girbardt, Johanna and Luck,
                      Tobias and Rodriguez, Francisca S and Plant, Gordon T and
                      Wicklein, Barbara and Wirkner, Kerstin and Engel, Christoph
                      and Kynast, Jana and Girbardt, Christian and Wang, Mengyu
                      and Polyakova, Maryna and Hinz, Andreas and Witte, A
                      Veronica and Kirsten, Toralf and Loeffler, Markus and
                      Villringer, Arno and Riedel-Heller, Steffi G and Elze,
                      Tobias and Rauscher, Franziska G},
      title        = {{R}etinal nerve fibre layer thickness is associated with
                      attention and predicts risk states of dementia.},
      journal      = {Brain communications},
      volume       = {7},
      number       = {6},
      issn         = {2632-1297},
      address      = {[Oxford]},
      publisher    = {Oxford University Press},
      reportid     = {DZNE-2025-01354},
      pages        = {fcaf464},
      year         = {2025},
      abstract     = {Alzheimer's disease is associated with lower
                      circumpapillary retinal nerve fibre layer thickness
                      (cpRNFLT). It remains unclear if dementia risk states, i.e.
                      mild cognitive impairment (MCI) and mild neurocognitive
                      disorder (NCD) might associate with cpRNFLT and whether
                      specific domains of cognitive function are related. The
                      present study compared systematically all cognitive domains
                      as defined in the Diagnostic and Statistical Manual of
                      Mental Disorders (DSM-5) with pointwise analyses of the
                      cpRNFLT and whether cpRNFLT variation can predict MCI and
                      mild NCD. Spectral domain optical coherence tomography scans
                      (768 A-scans of cpRNFLT) were analysed from 1300
                      participants with reliable measurements, without eye
                      diseases, and further exclusion due to brain disorders. The
                      study was conducted in the framework of the population-based
                      Leipzig Research Centre for Civilization
                      Diseases-(LIFE)-Adult study. The six DSM-5 domains were
                      operationalized by means of both (sub-)scales of the
                      'Consortium to Establish a Registry for Alzheimer Disease'
                      (CERAD-Plus) neuropsychological test battery and the
                      'Reading the Mind in the Eyes' test. Age, sex, education and
                      scanning radius were used as additional regressors to adjust
                      for demographics and eye anatomy. 2133 eyes of 1300 subjects
                      were selected (age range 60-79 years). After adjustment for
                      multiple comparisons, in the domain 'attention', worse
                      performance was related to significantly thinner cpRNFL,
                      especially in male participants, most pronounced for
                      temporal and nasal-superior locations. For the domain
                      'executive function' significantly thicker cpRNFL was found
                      nasally in female participants. There were no significant (P
                      < 0.05) cpRNFLT locations for the DSM-5 domains
                      'learning/memory', 'perceptual-motor abilities', 'language'
                      and 'social cognition'. Subjects with MCI had thinner cpRNFL
                      temporal-superior compared to subjects with normal
                      cognition. Furthermore, alterations of cpRNFLT in MCI and
                      mild NCD, and subgroups amnestic MCI and amnestic mild NCD
                      existed, for the latter mainly in temporal regions. Compared
                      to cognitively unimpaired, analyses revealed hippocampal
                      volume decreases in MCI and mild NCD groups, and comparable
                      white matter lesion volume, compatible with Alzheimer
                      aetiology. cpRNFL fibre thinning was most prominently
                      associated with lower performance in the attention domain.
                      Highly location specific thinning involved predominantly
                      retinal locations superior and temporal to the optic disc.
                      Thinning in temporal-superior segment was associated with
                      MCI. Temporal thinning indicated amnestic MCI and amnestic
                      mild NCD. Executive function, MCI, and mild NCD presented a
                      concordantly negative association of cognition and RNFLT
                      nasally. As cpRNFLT is obtained conveniently within seconds,
                      our results might assist clinicians by earlier
                      identification of patients at risk for developing cognitive
                      decline associated with diseases like Alzheimer's disease.},
      keywords     = {MRI (Other) / hippocampus (Other) / mild cognitive
                      impairment (Other) / neurocognitive disorder (Other) /
                      retinal nerve fibre layer thickness (Other)},
      cin          = {AG Rodriguez},
      ddc          = {610},
      cid          = {I:(DE-2719)1510900},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41357353},
      pmc          = {pmc:PMC12679710},
      doi          = {10.1093/braincomms/fcaf464},
      url          = {https://pub.dzne.de/record/282596},
}