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@ARTICLE{Streit:282599,
      author       = {Streit, Simon and Meinhardt, Jenny and Gimber, Niclas and
                      Kestenbach, John and Siewert, Christin and Schmoranzer, Jan
                      and Meisel, Christian and Ruprecht, Klemens and Heppner,
                      Frank L and Körtvélyessy, Péter and Stenzel, Werner},
      title        = {{N}eurofilament light chain as a marker of peripheral nerve
                      damage in vasculitic neuropathy? {A} cross-compartmental
                      correlation analysis in patients undergoing nerve biopsy.},
      journal      = {Brain pathology},
      volume       = {36},
      number       = {1},
      issn         = {1015-6305},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-01357},
      pages        = {e70038},
      year         = {2025},
      abstract     = {Vasculitic neuropathy remains challenging to diagnose and
                      monitor because of its heterogeneous clinical and laboratory
                      presentation. Blood-based biomarkers indicating nerve damage
                      could serve as an additional diagnostic tool to ensure early
                      diagnosis, precise therapeutic monitoring, and a more
                      targeted anti-inflammatory treatment. A potential marker for
                      this purpose is neurofilament light chain (NfL), a marker of
                      neuroaxonal damage that is used as a biomarker in several
                      diseases of the central and peripheral nervous system. NfL
                      has also been suggested to reflect disease activity in
                      patients with vasculitic neuropathy. However, its
                      biodynamics and link to degeneration of peripheral nerve
                      tissue remain unconfirmed. To investigate the usefulness of
                      NfL as a marker of peripheral nerve damage in this context,
                      we retrospectively assembled a cohort of 35 patients
                      undergoing sural nerve biopsies (including patients with
                      vasculitic neuropathy and other neuropathies). We then
                      measured NfL in serum samples cryoarchived at the time of
                      biopsy and correlated NfL levels with histological
                      parameters. For our histological analysis, we quantified
                      parameters of acute axonal degeneration and chronic axonal
                      loss using a combination of manual, threshold-based, and
                      supervised learning-based analyses. We found a significant
                      positive correlation between parameters of acute axonal
                      degeneration and serum-NfL levels that persisted after
                      adjusting for age and concomitant central nervous system
                      disease. We did not find a similar correlation with
                      parameters of chronic axonal loss quantified in nerve
                      biopsies. These findings support the value of NfL as a
                      marker for acute axonal degeneration in patients with
                      vasculitic neuropathy.},
      keywords     = {biomarker (Other) / histopathology (Other) / nerve biopsy
                      (Other) / neurofilament light chain (NfL) (Other) /
                      vasculitic neuropathy (Other) / vasculitis (Other)},
      cin          = {AG Heppner / AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)1810007 / I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40935795},
      doi          = {10.1111/bpa.70038},
      url          = {https://pub.dzne.de/record/282599},
}