TY  - JOUR
AU  - Schreiber, Tobias
AU  - von Rennenberg, Regina
AU  - Brämswig, Tim Bastian
AU  - Landmesser, Ulf
AU  - Hindricks, Gerhard
AU  - Nagel, Patrick
AU  - Tscholl, Verena
AU  - Huemer, Martin
AU  - Lucas, Johannes
AU  - Attanasio, Philipp
AU  - Nolte, Christian H
TI  - Comparison of Cerebral Micro-Embolization Detected by Transcranial Doppler Examination Between Radiofrequency Ablation and Pulsed Field Ablation for Atrial Fibrillation.
JO  - Journal of cardiovascular electrophysiology
VL  - 36
IS  - 12
SN  - 1045-3873
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DZNE-2025-01358
SP  - 3288 - 3295
PY  - 2025
AB  - Pulsed Field Ablation (PFA) can establish pulmonary vein isolation via irreversible electroporation and is believed to reduce overall complications; however, periprocedural stroke has also been reported after PFA procedures. Assessment of microembolic signals (MES) measured by transcranial doppler (TCD) allows to monitor cerebral embolization during the procedure and to identify higher risk procedural steps. This study was designed to compare the incidence of MES during different procedural steps between two different PFA systems and radiofrequency ablation (RFA).Pulmonary vein isolation was performed either using either high-power short-duration radiofrequency ablation (HPSD RFA), or PFA using a variable loop circular catheter (VLCC) or a circular multielectrode array catheter (CMAC). MES were compared during transseptal puncture, ablation, left atrial mapping, and introduction/retraction of catheters. Neurological examination was performed pre and post ablation for all patients including the National Institutes of Health Stroke Scale (NIHSS). Fifty-six consecutive patients (19 female (34
KW  - Humans
KW  - Ultrasonography, Doppler, Transcranial
KW  - Female
KW  - Atrial Fibrillation: surgery
KW  - Atrial Fibrillation: diagnosis
KW  - Atrial Fibrillation: physiopathology
KW  - Atrial Fibrillation: epidemiology
KW  - Male
KW  - Aged
KW  - Catheter Ablation: adverse effects
KW  - Catheter Ablation: methods
KW  - Catheter Ablation: instrumentation
KW  - Intracranial Embolism: diagnostic imaging
KW  - Intracranial Embolism: epidemiology
KW  - Intracranial Embolism: etiology
KW  - Pulmonary Veins: surgery
KW  - Pulmonary Veins: physiopathology
KW  - Middle Aged
KW  - Treatment Outcome
KW  - Predictive Value of Tests
KW  - Time Factors
KW  - Incidence
KW  - Risk Factors
KW  - atrial fibrillation (Other)
KW  - microembolism (Other)
KW  - pulsed field ablation (Other)
KW  - radiofrequency ablation (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC12697227
C6  - pmid:41078013
DO  - DOI:10.1111/jce.70140
UR  - https://pub.dzne.de/record/282600
ER  -